CGRPR/CALCRL-RAMP1 Full-Length Nanodisc and MNP Proteins

The calcitonin gene-related peptide receptor is a heteromeric receptor complex formed primarily by CALCRL and RAMP1. CALCRL belongs to the class B GPCR family, which also includes GIPR, GCGR, GLP1R, and PTH1R. Association with receptor activity-modifying proteins determines CALCRL pharmacology: CALCRL with RAMP1 forms the canonical CGRP receptor, whereas complexes with RAMP2 or RAMP3 display greater responsiveness to adrenomedullin-family ligands. CGRP activation of CALCRL-RAMP1 stimulates Gs-cAMP signaling and regulates sensory-neuron activity, neurogenic inflammation, and vascular tone. This biology makes CGRPR a central receptor in migraine and neurovascular research. Because functional receptor architecture depends on assembly of both CALCRL and RAMP1, intact receptor-complex presentation can provide a more physiologically relevant screening antigen than soluble CALCRL alone.

DIMA BIOTECH provides full-length human CGRPR-RAMP1 receptor complexes in Synthetic Nanodisc and membrane nanoparticle formats, including a biotinylated Synthetic Nanodisc version. These reagents support native-complex antibody screening, SPR/BLI, ligand-receptor studies, and binding characterization. Recombinant CALCRL extracellular proteins and flow cytometry-compatible reference antibodies provide complementary tools for biochemical and cellular studies.