GUCY2C/GCC Recombinant Proteins and Flow Antibodies

GUCY2C (Guanylate Cyclase 2C), also known as GCC, is a single-pass receptor guanylate cyclase expressed predominantly by intestinal epithelial cells. Its endogenous ligands include guanylin and uroguanylin. Ligand engagement activates the intracellular guanylate-cyclase domain, increasing cGMP and regulating electrolyte transport, epithelial homeostasis, and barrier function through PKG and downstream ion-transport pathways. GUCY2C expression is retained in many colorectal and other gastrointestinal malignancies. In healthy intestine the receptor is largely oriented toward the luminal surface, whereas disruption of tissue architecture in cancer can increase accessibility to systemically delivered targeting molecules. These properties have generated interest in GUCY2C for antibodies, ADCs, T-cell engagers, and engineered cell therapies.

DIMA BIOTECH provides multiple GUCY2C recombinant ECD proteins for ELISA, ligand-binding studies, antibody screening, and epitope characterization. Flow cytometry-validated monoclonal and reference antibodies support cell-surface GCC detection, candidate benchmarking, and assay development. These reagents can be integrated with downstream cell-binding, internalization, and functional assays for GUCY2C-targeted biologic development, helping identify candidate antibodies with appropriate epitope recognition and cellular activity.