IL7RA/CD127 Recombinant Proteins and Flow Antibodies

Interleukin-7 Receptor AlphaI (L7RA), also known as CD127, is a key cytokine-receptor subunit controlling lymphocyte development and homeostasis. Association of IL7RA with the common gamma chain/CD132 forms the functional IL-7 receptor, which activates JAK1/JAK3, STAT5, PI3K/AKT, and related pathways to support T-cell precursor development, mature T-cell survival, and memory T-cell maintenance. IL7RA also pairs with CRLF2 to form the receptor for TSLP, connecting lymphocyte biology with epithelial-derived inflammatory signaling. CD127 is expressed on many conventional T-cell populations but is typically low on mature regulatory T cells, making it a useful marker in immune phenotyping. Dysregulated IL7RA signaling has been investigated in autoimmunity, chronic inflammation, and lymphoid disease.

DIMA BIOTECH provides recombinant human IL7RA ECD protein for IL-7/IL7RA and TSLP-receptor-related binding studies, ELISA, SPR/BLI, and antibody screening. A flow cytometry-validated chimeric monoclonal antibody and multiple reference antibodies, including biotinylated formats, support CD127 cell-surface detection, T-cell subset analysis, receptor occupancy, and candidate blocking-antibody comparison.