TNFRSF10B/DR5 Recombinant Proteins, Antibodies and Stable Cell Lines

TNFRSF10B, also known as DR5 or TRAIL-R2, is a death receptor of the TNF receptor superfamily. Its extracellular region binds TRAIL, while its intracellular death domain recruits FADD and procaspase-8/10 following receptor clustering, initiating the extrinsic apoptotic pathway. DR5 is expressed on many tumor-cell types and has therefore attracted long-standing interest in agonistic antibodies, receptor-clustering molecules, and multispecific formats designed to trigger programmed cell death. Functional activity depends strongly on receptor clustering, antibody epitope, valency, and Fc-mediated crosslinking, meaning that high-affinity binding alone may not predict agonistic potency.

DIMA BIOTECH provides recombinant DR5 ECD proteins for TRAIL-DR5 interaction studies, ELISA, SPR/BLI, antibody screening, and epitope characterization. Multiple monoclonal and reference antibodies, including flow-cytometry-compatible formats, support cell-surface DR5 detection and candidate comparison. A DR5-overexpressing stable cell line provides a standardized platform for FACS, cell binding, receptor-clustering studies, and agonistic-antibody screening. Together, these tools help distinguish candidates with strong biochemical binding from those capable of driving productive receptor activation and cellular apoptosis.