Name: Human MCLN2-Strep full length protein-synthetic nanodisc - DIMA Biotechnology
SKU: FLP120770

Tag	C-Flag&Strep Tag
Target	MCLN2
Synonyms	TRP-ML2, TRPML2
Description	Human MCLN2-Strep full length protein-synthetic nanodisc
Delivery	6~8weeks
Uniprot ID	Q8IZK6
Expression Host	HEK293
Protein Families	Ion Channels: Transient receptor potential
Protein Pathways	N/A
Molecular Weight	The human full length MCLN2-Strep protein has a MW of 65.9 kDa
Formulation & Reconstitution	Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
Storage & Shipping	Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Background	Mucolipins constitute a family of cation channel proteins with homology to the transient receptor potential superfamily. In mammals, the mucolipin family includes 3 members, MCOLN1 (MIM 605248), MCOLN2, and MCOLN3 (MIM 607400), that exhibit a common 6-membrane-spanning topology. Homologs of mammalian mucolipins exist in Drosophila and C. elegans. Mutations in the human MCOLN1 gene cause mucolipodosis IV (MIM 262650) (Karacsonyi et al., 2007 [PubMed 17662026]).[supplied by OMIM, Sep 2009]
Usage	Research use only
Conjugate	Unconjugated

Human MCLN2-Strep full length protein-synthetic nanodisc