Human CS1 Protein, hFc-His Tag
|Package||10 μg $70.00 ; 50 μg $280.00 ; 100 μg $410.00|
|Description||Recombinant human CS1 protein with C-terminal human Fc and 6×His tag|
|Synonyms||SLAMF7, CD319, CS1, CRACC, 19A, FOAP-12|
|Tag||C-Human Fc and 6×His tag|
|Molecular Weight||The protein has a predicted molecular mass of 70 kDa after removal of the signal peptide.|
|Purity||The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.|
|Formulation & Reconstitution||Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions.|
|Storage||Store at -80°C for 12 months (Avoid repeated freezing and thawing)|
|Usage||Research use only|
Figure 1. Human CS1, hFc-His Tag on SDS-PAGE under reducing condition.
Figure 2. ELISA plate pre-coated by 2 μg/ml (100 μl/well) Human CS1, hFc-His tagged protein (PME100002) can bind Anti-CS1 Neutralizing antibody (BME100002) in a linear range of 7.81-210.7 ng/ml.
|Background||SLAM family member 7 (SLAMF7) is also known as CD2-like receptor-activating cytotoxic cells (CRACC), Membrane protein FOAP-12, CD antigen CD319, Novel Ly9, Protein 19A, which is a single-pass type I membrane protein and a member of the CD2 family of cell surface receptors. SLAMF7 is expressed in spleen, lymph node, peripheral blood leukocytes, bone marrow, small intestine, stomach, appendix, lung and trachea. Isoform 1 of SLAMF7 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway. May play a role in lymphocyte adhesion. Isoform 3 of SLAMF7 does not mediate any NK cell activation.|