| Common Name | CSL-362-AML, CSL362, JNJ-56022473 |
|---|---|
| Synonyms | CD123;IL3R;IL3RA |
| Conjugate | Unconjugated |
| Applications | ELISA; Flow Cyt |
| Recommended Dilutions | ELISA 1:5000-10000; Flow Cyt 1:100 |
| Formulation & Reconstitution | Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
| Host Species | Humanized |
| IgG type | Human IgG1 – kappa |
| Reactivity | Human |
| Target | |
| Uniprot ID | P26951 |
| Description | Anti-CD123 (talacotuzumab biosimilar) mAb |
| Delivery | In Stock |
| Storage & Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Background | Research grade biosimilar. Not for use in therapeutic or diagnostic procedures for humans or animals. |
| Usage | Research use only |
| DIMA Disclaimer | All DIMA recombinant antibodies are genuinely generated by DIMA Biotech. They are all under patent application. Any protein sequencing or reverse engineering attempt is prohibited. We are actively scrutinizing all patent application to ensure no IP infringement. |
Anti-CD123 (talacotuzumab biosimilar) mAb
Price: 50μg $82.00 ; 100 μg $162.00
Product Data Dima FAQ
Images Dima FAQ
Figure 1. ELISA plate pre-coated by 2 μg/ml (100 μL/well) Human CD123, hFc-His tagged protein (PME100003) can bind Anti-CD123 Neutralizing antibody in a linear range of 0.98-26.70 ng/ml. In order to specifically detect BME100003, mouse anti-human Fab-specific antibody was used as detection antibody.
Figure 2. HEK293 cell line transfected with irrelevant protein (B) and human CD123 (A) were surface stained with anti-CD123 neutralizing antibody 1μg/ml (talacotuzumab) followed by Alexa 488-conjugated anti-human IgG secondary antibody.
Figure 3. Flow cytometry analysis of antigen binding of anti-human CD123 mAb(BME100003).
(A) A clear peak shift of BME100003 was seen compared to the control when incubated with CD123-expressing 8226 cells, indicating strong binding of BME100003 to CD123. Antibodies were incubated at 2 μg/mL.
Figure 4. Flow cytometry analysis of antigen binding of anti-human CD123 mAb(BME100003).
(A) BME100003 does not bind to CHO-S cells that do not express CD123.
(B) A clear peak shift of BME100003 was seen compared to the control when incubated with CD123-expressing THP-1 cells, indicating strong binding of BME100003 to CD123. Antibodies were incubated at 5 μg/mL.
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