| Clone ID | DM106 |
|---|---|
| Target | |
| Synonyms | CSF1R;C-FMS;CD115;CSFR;FIM2;FMS;M-CSFR |
| Host Species | Rabbit |
| Description | Anti-CSF1R antibody(DM106); Rabbit mAb |
| Delivery | In Stock |
| Uniprot ID | P07333 |
| IgG type | Rabbit IgG |
| Clonality | Monoclonal |
| Reactivity | Human |
| Applications | ELISA; Flow Cyt |
| Recommended Dilutions | ELISA 1:5000-10000; Flow Cyt 1:100 |
| Purification | Purified from cell culture supernatant by affinity chromatography |
| Endotoxin | Less than 1.0 EU/μg by the LAL method. For <1 EU/mg requirements, please contact us for customization. |
| Formulation & Reconstitution | Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
| Storage&Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Background | The protein encoded by this gene is the receptor for colony stimulating factor 1; a cytokine which controls the production; differentiation; and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1:PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Alternative splicing results in multiple transcript variants. Expression of a splice variant from an LTR promoter has been found in Hodgkin lymphoma (HL); HL cell lines and anaplastic large cell lymphoma. |
| Usage | Research use only |
| Conjugate | Unconjugated |
| DIMA Disclaimer | All DIMA recombinant antibodies are genuinely generated by DIMA Biotech. They are all under patent application. Any protein sequencing or reverse engineering attempt is prohibited. We are actively scr |
Anti-CSF1R antibody(DM106); Rabbit mAb
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Product Data Dima FAQ
Images Dima FAQ
Figure 1. ELISA plate pre-coated by 2 μg/ml (100 μl/well) Human CSF1R protein,His tagged protein PME100067 can bind Rabbit anti- CSF1R monoclonal antibody (clone: DM106) in a linear range of 0.6-60 ng/ml.
Figure 2. Flow cytometry analysis with Anti-CSF1R (DM106) on HEK293 cells transfected with human CSF1R(Blue histogram)or HEK293 transfected with irrelevant protein (Red histogram).
Figure 3. Flow cytometry analysis of antigen binding of rabbit anti-human CSF1R mAb(DME100106).
(A) DME100106 does not bind to CHO-S cells that do not express CSF1R.
(B) A clear peak shift of DME100106 was seen compared to the control when incubated with CSF1R-expressing THP-1 cells, indicating strong binding of DME100106 to CSF1R. Antibodies were incubated at 5 μg/mL.
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