| Uniprot ID | P24394 |
|---|---|
| Formulation & Reconstitution | Powder |
| Synonyms | CD124, IL-4RA, IL4RA |
| Storage & Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized antibodies are shipped at ambient temperature. |
| Description | Anti-IL4RA antibody(DMC284), IgG1 Chimeric mAb |
| Target | |
| Recommended Dilutions | Flow Cyt 1/100 |
| Applications | Flow Cyt |
| Host Species | Rabbit |
| IgG type | Rabbit/Human Fc chimeric IgG1 |
| Clonality | Monoclonal |
| Reactivity | Human |
| Purification | Purified from cell culture supernatant by affinity chromatography |
| Buffer | 1XPBS |
| Delivery | In Stock |
| Usage | Research use only |
| Background | This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants. |
Anti-IL4RA antibody(DMC284), IgG1 Chimeric mAb
Price: 10μg $99.00 ; 100 μg $438.00 ; 500 μg $1314.00
Product Data
Images
Figure 1. Flow cytometry analysis with Anti-IL4RA (DMC284) on Expi293 cells transfected with human IL4RA (Blue histogram) or Expi293 transfected with irrelevant protein (Red histogram).