Clone ID | DMC284 |
---|---|
Target | |
Synonyms | CD124; IL-4RA; IL4RA |
Host Species | Rabbit |
Description | Anti-IL4RA antibody(DMC284); IgG1 Chimeric mAb |
Delivery | In Stock |
Uniprot ID | P24394 |
IgG type | Rabbit/Human Fc chimeric IgG1 |
Clonality | Monoclonal |
Reactivity | Human |
Applications | Flow Cyt |
Recommended Dilutions | Flow Cyt 1:100 |
Purification | Purified from cell culture supernatant by affinity chromatography |
Formulation & Reconstitution | Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
Storage & Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
Background | This gene encodes the alpha chain of the interleukin-4 receptor; a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein; and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy; a condition that can manifest itself as allergic rhinitis; sinusitus; asthma; or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants. |
Usage | Research use only |
Conjugate | Unconjugated |
Anti-IL4RA antibody(DMC284); IgG1 Chimeric mAb
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Product Data
Images
Figure 1. Flow cytometry analysis with Anti-IL4RA (DMC284) on Expi293 cells transfected with human IL4RA (Blue histogram) or Expi293 transfected with irrelevant protein (Red histogram).
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