Uniprot ID | P24394 |
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Formulation & Reconstitution | Powder |
Synonyms | CD124, IL-4RA, IL4RA |
Storage & Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized antibodies are shipped at ambient temperature. |
Description | Anti-IL4RA antibody(DMC284), IgG1 Chimeric mAb |
Target | |
Recommended Dilutions | Flow Cyt 1/100 |
Applications | Flow Cyt |
Host Species | Rabbit |
IgG type | Rabbit/Human Fc chimeric IgG1 |
Clonality | Monoclonal |
Reactivity | Human |
Purification | Purified from cell culture supernatant by affinity chromatography |
Buffer | 1XPBS |
Delivery | In Stock |
Usage | Research use only |
Background | This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants. |
Anti-IL4RA antibody(DMC284), IgG1 Chimeric mAb
Price: 10μg $99.00 ; 100 μg $438.00 ; 500 μg $1314.00
Product Data
Images
Figure 1. Flow cytometry analysis with Anti-IL4RA (DMC284) on Expi293 cells transfected with human IL4RA (Blue histogram) or Expi293 transfected with irrelevant protein (Red histogram).