Clone ID | DMC438 |
---|---|
Target | |
Synonyms | EDSS1; LNIR; nectin-4; PRR4; PVRL4 |
Host Species | Rabbit |
Description | Anti-Nectin4 antibody(DMC438); IgG1 Chimeric mAb |
Delivery | In Stock |
Uniprot ID | Q96NY8 |
IgG type | Rabbit/Human Fc chimeric IgG1 |
Clonality | Monoclonal |
Reactivity | Human |
Applications | Flow Cyt |
Recommended Dilutions | Flow Cyt 1:100 |
Purification | Purified from cell culture supernatant by affinity chromatography |
Formulation & Reconstitution | Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
Storage & Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
Background | This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17:TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1; an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined. |
Usage | Research use only |
Conjugate | Unconjugated |
Anti-Nectin4 antibody(DMC438); IgG1 Chimeric mAb
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Product Data
Images
Figure 1. Flow cytometry analysis with Anti-Nectin4 (DMC438) on Expi293 cells transfected with human Nectin4 (Blue histogram) or Expi293 transfected with irrelevant protein (Red histogram).
Figure 2. Flow cytometry analysis of antigen binding of anti-human Nectin4 mAb(DMC100438).
(A) DMC100438 does not bind to 293T cells that do not express Nectin4.
(B) A clear peak shift of DMC100438 was seen compared to the control when incubated with Nectin4-expressing A431 cells, indicating strong binding of DMC100438 to Nectin4. Antibodies were incubated at 2 μg/mL.
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