Uniprot ID | P26718 |
---|---|
Applications | Flow Cyt |
Delivery | In Stock |
Package | 10μg $99.00 ; 100 μg $438.00 ; 500 μg $1314.00 |
Formulation & Reconstitution | Powder |
Tag | |
Recommended Dilutions | Flow Cyt 1/100 |
Target | |
Description | Anti-NKG2D antibody(DMC287), IgG1 Chimeric mAb |
Storage & Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized antibodies are shipped at ambient temperature. |
Synonyms | NKG2D,CD314,KLRK1,NK cell receptor D |
Host Species | Rabbit |
IgG type | Rabbit/Human Fc chimeric IgG1 |
Clonality | Monoclonal |
Reactivity | Human |
Purification | Purified from cell culture supernatant by affinity chromatography |
Buffer | 1XPBS |
Usage | Research use only |
Background | Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. This gene encodes a member of the NKG2 family. The encoded transmembrane protein is characterized by a type II membrane orientation (has an extracellular C terminus) and the presence of a C-type lectin domain. It binds to a diverse family of ligands that include MHC class I chain-related A and B proteins and UL-16 binding proteins, where ligand-receptor interactions can result in the activation of NK and T cells. The surface expression of these ligands is important for the recognition of stressed cells by the immune system, and thus this protein and its ligands are therapeutic targets for the treatment of immune diseases and cancers. Read-through transcription exists between this gene and the upstream KLRC4 (killer cell lectin-like receptor subfamily C, member 4) family member in the same cluster. |
Anti-NKG2D antibody(DMC287), IgG1 Chimeric mAb
Price: 10μg $99.00 ; 100 μg $438.00 ; 500 μg $1314.00
Product Data
Images
Figure 1. Flow cytometry analysis with Anti-NKG2D (DMC287) on Expi293 cells transfected with human NKG2D (Blue histogram) or Expi293 transfected with irrelevant protein (Red histogram).