Awaiting product image

Human CCR10 full length protein-synthetic nanodisc

Price: 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00

SKU: FLP100219 Category:
Datasheet
MSDS
Product Data
Target

Synonyms

GPR2
Description

Human CCR10 full length protein-synthetic nanodisc
Delivery

6~8weeks
Uniprot ID

P46092
Expression Host

HEK293
Protein Families

GPCR,Transmembrane,Druggable Genome,
Protein Pathways

GPCRDB Class A Rhodopsin-like,Peptide GPCRs,Angiogenesis,Chemokines,Asthma,Autoimmune & Inflammatory Response,Chemokine and Receptor,
Molecular Weight

The human full length CCR10 protein has a MW of 38.4kDa
Formulation & Reconstitution

Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions.
Storage & Shipping

Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Background

Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines. CCR10 is the receptor for CCL27 (SCYA27; MIM 604833); CCR10-CCL27 interactions are involved in T cell-mediated skin inflammation (Homey et al., 2002 [PubMed 11821900]).[supplied by OMIM, Mar 2008]
Usage

Research use only
Images