| Package | 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00 |
|---|---|
| Molecular Weight | The human full length FZD7 protein has a MW of 63.4 kDa |
| Delivery | 3-4 weeks |
| Formulation & Reconstitution | Supplied in nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0) |
| Target | |
| Storage & Shipping | The product should be stored at -80°C. Please do not repeated freeze-thaw cycles. |
| Uniprot ID | O75084 |
| Protein Families | Druggable Genome, Transmembrane |
| Protein Pathways | Basal cell carcinoma, Colorectal cancer, Melanogenesis, Pathways in cancer, Wnt signaling pathway |
| Synonyms | FzE3 |
| Expression Host | HEK293 |
| Description | Human FZD7 full length protein-synthetic nanodisc |
| Background | Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas. [provided by RefSeq, Jul 2008] |
Human FZD7 full length protein-synthetic nanodisc
Price: 10ug$900.00;50 μg $4400.00 ; 100 μg $8000.00