Package | 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00 |
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Molecular Weight | The human full length MRGPRX2 protein has a MW of 37.1 kDa |
Delivery | 3-4 weeks |
Formulation & Reconstitution | Supplied in nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0) |
Target | |
Storage & Shipping | The product should be stored at -80°C. Please do not repeated freeze-thaw cycles. |
Uniprot ID | Q96LB1 |
Protein Families | Druggable Genome, GPCR, Transmembrane |
Protein Pathways | |
Synonyms | MGRG3; MRGX2 |
Expression Host | HEK293 |
Description | Human MRGPRX2 full length protein-synthetic nanodisc |
Background | Mast cell-specific receptor for basic secretagogues, i.e. cationic amphiphilic drugs, as well as endo- or exogenous peptides, consisting of a basic head group and a hydrophobic core (PubMed:25517090). Recognizes and binds small molecules containing a cyclized tetrahydroisoquinoline (THIQ), such as non-steroidal neuromuscular blocking drugs (NMBDs), including tubocurarine and atracurium. In response to these compounds, mediates pseudo-allergic reactions characterized by histamine release, inflammation and airway contraction (By similarity). Acts as a receptor for a number of other ligands, including peptides and alkaloids, such as cortistatin-14, proadrenomedullin N-terminal peptides PAMP-12 and, at lower extent, PAMP-20, antibacterial protein LL-37, PMX-53 peptide, beta-defensins, and complanadine A.[UniProtKB/Swiss-Prot Function] |

Human MRGPRX2 full length protein-synthetic nanodisc
Price: 10ug$900.00;50 μg $4400.00 ; 100 μg $8000.00