Recombinant mouse GITR Ligand protein with N-terminal human Fc tag
N-Human Fc Tag
hFc(Glu99-Ala330) Mouse GITR Ligand(Thr47-Ser173)
The protein has a predicted molecular mass of 40.6 kDa after removal of the signal peptide. The apparent molecular mass of hFc-mGITRL is approximately 40-55 kDa due to glycosylation.
The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
|Formulation & Reconstitution||
Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
|Storage & Shipping||
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Cytokine that binds to TNFRSF18/AITR/GITR (PubMed:14521928, PubMed:14647196). Regulates T-cell responses (PubMed:14647196). Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation (PubMed:14608036, PubMed:15128759). Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B (PubMed:14521928, PubMed:14647196, PubMed:18178614). Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 (By similarity). Promotes leukocyte adhesion to endothelial cells (PubMed:23892569). Regulates migration of monocytes from the splenic reservoir to sites of inflammation (PubMed:24107315).[UniProtKB/Swiss-Prot Function]
Research use only
Mouse GITR Ligand Protein, hFc Tag
Price: 10μg $100.00 ; 50μg $375.00 ; 100 μg $550.00
SKU: PME-M100066 Category: ECD Proteins
Figure 1. Mouse GITR Ligand Protein, hFc Tag on SDS-PAGE under reducing condition.