Product Targets:
| 2B4 | 4-1BB | 4-1BB-L | SIRPα |
| B7-H3 | BCMA | CD123 | CD48 |
| CD138 | CD22 | CD27 | GITR Ligand |
| CD28 | CD38 | CD47 | CS1 |
| GPRC5D | CTLA-4 | MSLN | TROP2 |
| GITR | TIM3 | B7-2 | PSCA |
| NKp30 | BTN3A1 | DNAM1 | B7-H2 |
| CD40 |
DIMA mAbs Rabbit Monoclonal Antibodies
Compared with other animals, rabbits have a unique process of B cell development and are farther apart than rodents and humans. In addition, rabbit B cells have a dual affinity maturation mechanism, including gene conversion and SHM (somatic hypermutation). At the same time, the protein structure of rabbit IgG is different from that of mouse IgG, which is reflected in that it has only one subtype of IgG and its CDR3 region is longer than mouse CDR3. These differences make rabbit produce monoclonal antibodies with higher affinity and specificity.
DIMA Biotechnology Ltd. is a biotech company focusing on preclinical R&D products and services for druggable targets. We plan to complete the preparation of lead antibody molecules for all druggable targets in the next 3-5 years. Currently, we have developed over 1000 monoclonal antibodies for cancer targets. Scientists can skip the tedious steps of antibody development and screening. They can have more time to study the biological mechanism and developability of drug targets, thus accelerating the process of new drug R&D.
DIMA’s rabbit monoclonal antibodies are developed using our own proprietary DIMA monoclonal antibody development platform. All our antibodies are raised against the potential diagnostic, prognostic and therapeutic targets. We used functional proteins as antigens and verified the antibodies with various applications and protein samples. Most of our monoclonal antibodies show comparable or better specificities and affinities comparing to the reference antibodies. In addition to the specificity and affinity, DIMA’s recombinant monoclonal antibodies also show high level of batch-to-batch consistency, because our single B cell cloning technology can directly isolate IgG gene from positive rabbit B cells, which significantly lower risk of the loss of hybridoma cells.
Product Advantage:
High affinity and high specificity
Figure 1. A) Flow cytometry data of serially titrated Rabbit anti-SIRPα monoclonal antibody (clone: DM8). The Y-axis represents the mean fluorescence intensity (MFI) while the X-axis represents the concentration of IgG used. B) Competition assay demonstrating DM8 blockade of CD47 binding to THP-1 cells. IC50=30.88ng/ml.
Multiple candidate clones of a single target showed high selectivity
Figure 2. Affinity ranking of different Rabbit anti-CS1 mAb clones by titration of different concentration onto Raji cells. The Y-axis represents the mean fluorescence intensity (MFI) while the X-axis represents the concentration of IgG used.
The List of DIMA BIOTECH's Rabbit MAbs
Monoclonal antibodies
SKU: DME100115B Target: TNFRSF10B
Application: ELISA; Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DME100114B Target: TNFRSF10B
Application: ELISA; Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DME100113B Target: TNFRSF10B
Application: ELISA; Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DME100112B Target: OX40 Ligand
Application: ELISA; Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DME100111B Target: B7-1
Application: ELISA; Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DME100110B Target: B7-1
Application: ELISA; Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DME100109B Target: B7-1
Application: ELISA; Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DME100108B Target: CSF1R
Application: ELISA; Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DME100107B Target: CSF1R
Application: ELISA; Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DME100106B Target: CSF1R
Application: ELISA; Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DME100105B Target: CD30
Application: ELISA; Flow Cyt; WB
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DME100104B Target: CD30
Application: ELISA; Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DME100103B Target: CD30
Application: ELISA; Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DME100055B Target: S protein RBD
Application: ELISA; Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DME100054B Target: S protein RBD
Application: ELISA; Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DME100128B Target: EGFR
Application: ELISA; Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
Biotinylated Anti-SARS-CoV-2 Spike antibody(DM42); Rabbit mAb
SKU: DME100041B Target: S protein
Application: ELISA
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
Biotinylated Anti-SARS-CoV-2 Spike antibody(DM41); Rabbit mAb
SKU: DME100040B Target: S protein
Application: ELISA
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
Biotinylated Anti-SARS-CoV-2 Spike antibody(DM40); Rabbit mAb
SKU: DME100039B Target: S protein
Application: ELISA
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
Biotinylated Anti-SARS-CoV-2 Spike antibody(DM39); Rabbit mAb
SKU: DME100038B Target: S protein
Application: ELISA
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
Biotinylated Anti-SARS-CoV-2 Nucleocapsid antibody(DM38); Rabbit mAb
SKU: DME100037B Target: Nucleocapsid
Application: ELISA
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
Biotinylated Anti-SARS-CoV-2 Nucleocapsid antibody(DM37); Rabbit mAb
SKU: DME100036B Target: Nucleocapsid
Application: ELISA
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
Biotinylated Anti-SARS-CoV-2 Nucleocapsid antibody(DM36); Rabbit mAb
SKU: DME100035B Target: Nucleocapsid
Application: ELISA
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DME100034B Target: S protein RBD
Application: ELISA; Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DME100026B Target: S protein RBD
Application: ELISA; Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DME100025B Target: S protein RBD
Application: ELISA; Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
Biotinylated Anti-SARS-CoV-2 Spike antibody(DM25); Rabbit mAb
SKU: DME100018B Target: S protein
Application: ELISA
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
Biotinylated Anti-SARS-CoV-2 Spike antibody(DM24); Rabbit mAb
SKU: DME100017B Target: S protein
Application: ELISA
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
Biotinylated Anti-SARS-CoV-2 Nucleocapsid antibody(DM23); Rabbit mAb
SKU: DME100016B Target: Nucleocapsid
Application: ELISA
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
Biotinylated Anti-SARS-CoV-2 Nucleocapsid antibody(DM22); Rabbit mAb
SKU: DME100015B Target: Nucleocapsid
Application: ELISA
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DME100001B Target: His Tag
Application: ELISA; WB
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DME201008 Target: DDK
Application: ELISA, WB
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00