Product Targets:
| 2B4 | 4-1BB | 4-1BB-L | SIRPα |
| B7-H3 | BCMA | CD123 | CD48 |
| CD138 | CD22 | CD27 | GITR Ligand |
| CD28 | CD38 | CD47 | CS1 |
| GPRC5D | CTLA-4 | MSLN | TROP2 |
| GITR | TIM3 | B7-2 | PSCA |
| NKp30 | BTN3A1 | DNAM1 | B7-H2 |
| CD40 |
DIMA mAbs Rabbit Monoclonal Antibodies
Compared with other animals, rabbits have a unique process of B cell development and are farther apart than rodents and humans. In addition, rabbit B cells have a dual affinity maturation mechanism, including gene conversion and SHM (somatic hypermutation). At the same time, the protein structure of rabbit IgG is different from that of mouse IgG, which is reflected in that it has only one subtype of IgG and its CDR3 region is longer than mouse CDR3. These differences make rabbit produce monoclonal antibodies with higher affinity and specificity.
DIMA Biotechnology Ltd. is a biotech company focusing on preclinical R&D products and services for druggable targets. We plan to complete the preparation of lead antibody molecules for all druggable targets in the next 3-5 years. Currently, we have developed over 1000 monoclonal antibodies for cancer targets. Scientists can skip the tedious steps of antibody development and screening. They can have more time to study the biological mechanism and developability of drug targets, thus accelerating the process of new drug R&D.
DIMA’s rabbit monoclonal antibodies are developed using our own proprietary DIMA monoclonal antibody development platform. All our antibodies are raised against the potential diagnostic, prognostic and therapeutic targets. We used functional proteins as antigens and verified the antibodies with various applications and protein samples. Most of our monoclonal antibodies show comparable or better specificities and affinities comparing to the reference antibodies. In addition to the specificity and affinity, DIMA’s recombinant monoclonal antibodies also show high level of batch-to-batch consistency, because our single B cell cloning technology can directly isolate IgG gene from positive rabbit B cells, which significantly lower risk of the loss of hybridoma cells.
Product Advantage:
High affinity and high specificity
Figure 1. A) Flow cytometry data of serially titrated Rabbit anti-SIRPα monoclonal antibody (clone: DM8). The Y-axis represents the mean fluorescence intensity (MFI) while the X-axis represents the concentration of IgG used. B) Competition assay demonstrating DM8 blockade of CD47 binding to THP-1 cells. IC50=30.88ng/ml.
Multiple candidate clones of a single target showed high selectivity
Figure 2. Affinity ranking of different Rabbit anti-CS1 mAb clones by titration of different concentration onto Raji cells. The Y-axis represents the mean fluorescence intensity (MFI) while the X-axis represents the concentration of IgG used.
The List of DIMA BIOTECH's Rabbit MAbs
Monoclonal antibodies
SKU: DMB100003B Target: BCMA
Application: Flow Cyt; MM Tumor cell killing
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DMC100225B Target: IL21R
Application: ELISA; Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DMC100224B Target: CD112
Application: ELISA; Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DMC100223B Target: TREM2
Application: ELISA; Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DMC100222B Target: PCSK9
Application: ELISA; Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
Biotinylated Anti-IFNAR1 antibody(DMC221); IgG1 Chimeric mAb
SKU: DMC100221B Target: IFNAR1
Application: ELISA; Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DMC100220B Target: FCRL5
Application: ELISA; Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
Biotinylated Anti-FCGR3A antibody(DMC219); IgG1 Chimeric mAb
SKU: DMC100219B Target: FCGR3A
Application: ELISA; Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DME100218B Target: IL18RA
Application: ELISA; Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DMC100217B Target: CD24
Application: ELISA; Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DME100216B Target: GFAP
Application: ELISA
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DME100212B Target: CD47
Application: ELISA; Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DME100211B Target: CD43
Application: ELISA; Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DME100210B Target: DKK1
Application: ELISA; Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DME100209B Target: NRG1
Application: ELISA; Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DME100208B Target: CXCR3
Application: ELISA; Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DME100206B Target: IL15RA
Application: ELISA; Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DME100205B Target: ANGPTL3
Application: ELISA; Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DME100203B Target: CD99
Application: ELISA; Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DME100202B Target: CD56
Application: ELISA; Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DME100201B Target: CD30 Ligand
Application: ELISA; Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DME100200B Target: GM-CSF
Application: ELISA; Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DME100199B Target: NEFL
Application: ELISA
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DME100198B Target: NEFL
Application: ELISA
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DME100196B Target: CCR8
Application: ELISA; Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DME100194B Target: SCF
Application: ELISA; Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DME100193B Target: CD45
Application: ELISA; Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DME100192B Target: ADAM9
Application: ELISA; Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DME100190B Target: PGF
Application: ELISA; Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DME100189B Target: BCL2L1
Application: ELISA; Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DME100187B Target: IL2
Application: ELISA; Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DMC100213B Target: CD24
Application: ELISA; Flow Cyt; WB; IHC
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00