Product Targets:
| 2B4 | 4-1BB | 4-1BB-L | SIRPα |
| B7-H3 | BCMA | CD123 | CD48 |
| CD138 | CD22 | CD27 | GITR Ligand |
| CD28 | CD38 | CD47 | CS1 |
| GPRC5D | CTLA-4 | MSLN | TROP2 |
| GITR | TIM3 | B7-2 | PSCA |
| NKp30 | BTN3A1 | DNAM1 | B7-H2 |
| CD40 |
DIMA mAbs Rabbit Monoclonal Antibodies
Compared with other animals, rabbits have a unique process of B cell development and are farther apart than rodents and humans. In addition, rabbit B cells have a dual affinity maturation mechanism, including gene conversion and SHM (somatic hypermutation). At the same time, the protein structure of rabbit IgG is different from that of mouse IgG, which is reflected in that it has only one subtype of IgG and its CDR3 region is longer than mouse CDR3. These differences make rabbit produce monoclonal antibodies with higher affinity and specificity.
DIMA Biotechnology Ltd. is a biotech company focusing on preclinical R&D products and services for druggable targets. We plan to complete the preparation of lead antibody molecules for all druggable targets in the next 3-5 years. Currently, we have developed over 1000 monoclonal antibodies for cancer targets. Scientists can skip the tedious steps of antibody development and screening. They can have more time to study the biological mechanism and developability of drug targets, thus accelerating the process of new drug R&D.
DIMA’s rabbit monoclonal antibodies are developed using our own proprietary DIMA monoclonal antibody development platform. All our antibodies are raised against the potential diagnostic, prognostic and therapeutic targets. We used functional proteins as antigens and verified the antibodies with various applications and protein samples. Most of our monoclonal antibodies show comparable or better specificities and affinities comparing to the reference antibodies. In addition to the specificity and affinity, DIMA’s recombinant monoclonal antibodies also show high level of batch-to-batch consistency, because our single B cell cloning technology can directly isolate IgG gene from positive rabbit B cells, which significantly lower risk of the loss of hybridoma cells.
Product Advantage:
High affinity and high specificity
Figure 1. A) Flow cytometry data of serially titrated Rabbit anti-SIRPα monoclonal antibody (clone: DM8). The Y-axis represents the mean fluorescence intensity (MFI) while the X-axis represents the concentration of IgG used. B) Competition assay demonstrating DM8 blockade of CD47 binding to THP-1 cells. IC50=30.88ng/ml.
Multiple candidate clones of a single target showed high selectivity
Figure 2. Affinity ranking of different Rabbit anti-CS1 mAb clones by titration of different concentration onto Raji cells. The Y-axis represents the mean fluorescence intensity (MFI) while the X-axis represents the concentration of IgG used.
The List of DIMA BIOTECH's Rabbit MAbs
Monoclonal antibodies
SKU: DME100165B Target: CLEC12A
Application: ELISA; Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DME100164B Target: CD40 Ligand
Application: ELISA; Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DME100148B Target: IL2RA
Application: ELISA; Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DME100147B Target: EPCAM
Application: ELISA; Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DME100146B Target: CD155
Application: ELISA; Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DME100145B Target: CD46
Application: ELISA; Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DME100144B Target: CB1
Application: ELISA; Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DME100143B Target: BAFF-R
Application: ELISA; Flow Cyt; IHC
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DME100141B Target: TNFSF12
Application: ELISA; Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DME100140B Target: TNFSF12
Application: ELISA; Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DME100139B Target: 5T4
Application: ELISA; Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DME100138B Target: 5T4
Application: ELISA; Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DME100137B Target: 5T4
Application: ELISA; Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DME100136B Target: CD34
Application: ELISA; Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DME100135B Target: CD34
Application: ELISA; Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DME100134B Target: CD34
Application: ELISA; Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DME100133B Target: HVEM
Application: ELISA; Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DME100132B Target: HVEM
Application: ELISA; Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DME100131B Target: HVEM
Application: ELISA; Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DME100130B Target: EGFR
Application: ELISA; Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DME100129B Target: EGFR
Application: ELISA; Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DME100127B Target: BAFF-R
Application: Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DME100126B Target: IL17RA
Application: ELISA; Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DME100125B Target: IL17RA
Application: Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DME100124B Target: PDL1
Application: ELISA; Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DME100123B Target: PDL1
Application: ELISA; Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DME100122B Target: CEACAM5
Application: ELISA; Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DME100121B Target: CEACAM5
Application: ELISA; Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DME100120B Target: CEACAM5
Application: ELISA; Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DME100119B Target: CD7
Application: ELISA; Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DME100118B Target: CD7
Application: ELISA; Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DME100116B Target: OX40
Application: ELISA; Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00