Topics Archives: Ion channel

SCN2A: Molecular Mechanisms, NaV1.2 Function, and Precision Therapeutic Strategies for Early-Onset Epilepsy

In April 2025, a clinical case report in Nature Medicine offered groundbreaking evidence for precision therapeutics targeting SCN2A. The study described a neonate with early-onset, drug-resistant epilepsy caused by a gain-of-function (GoF) SCN2A mutation—encoding the α-subunit of the voltage-gated sodium channel NaV1.2. Following intrathecal administration of elsunersen, an SCN2A-targeting antisense oligonucleotide (ASO), the patient experienced a marked reduction in seizure frequency and showed early neurological improvement.

Blog 2025-12-11
The gene location and protein structure of TRPV1

TRPV1: An Important Target for Pain Treatment

Do you remember the temperature and touch receptor TRPV1 that made American scientists David Julius and Ardem Patapoutian accessible to the Nobel Prize in Physiology or Medicine in 2021? Transient Receptor Potential Vanilloid 1 (TRPV1) has gained significant attention in the field of pain treatment due to its potential as a therapeutic target. However, as […]

Blog , 2024-09-11

TRPA1, what a therapeutic target for pain!

The transient receptor potential ankyrin 1 (TRPA1) is a non-selective cation channel that allows the passage of Ca2+, thereby increasing intracellular Ca2+ levels. TRPA1 has garnered significant attention due to its ability to respond to various environmental stimuli and its involvement in pain perception and inflammatory processes. As of now, there are approximately 22 drugs […]

Blog , 2023-07-05