CD70/TNFSF7 Recombinant Proteins, Antibodies and Stable Cell Lines

CD70, also known as TNFSF7 or CD27 ligand, is a member of the tumor necrosis factor ligand superfamily and the natural ligand of the costimulatory receptor CD27. Under physiological conditions, CD70 expression is tightly controlled and transiently induced on activated T cells, B cells, and dendritic cells. CD70-CD27 signaling promotes T-cell expansion, survival, effector differentiation, and memory formation and also contributes to B-cell and NK-cell regulation. In contrast to its transient physiological expression, persistent CD70 surface expression can occur in selected hematologic and solid malignancies. This combination of tumor-associated expression, immune-regulatory activity, and receptor-mediated internalization makes CD70 attractive for monoclonal antibodies, ADCs, T-cell engagers, multispecific molecules, and engineered cell therapies.

DIMA BIOTECH provides multiple recombinant CD70 ECD proteins for CD27-CD70 interaction studies, ELISA, SPR/BLI, antibody screening, and affinity characterization. Flow cytometry-validated monoclonal antibodies, a broad panel of reference antibodies, and PE/biotin formats support cell-surface CD70 detection and candidate benchmarking. A CD70-overexpressing K562 stable cell line provides a standardized platform for FACS, cell-binding, internalization, and cell-based functional screening. Together, these products enable CD70 programs to progress from biochemical interaction studies to cellular candidate evaluation.