Glypican-3/GPC3 Recombinant Proteins, Flow Antibodies and Stable Cell Lines

Glypican-3 (GPC3) is a cell-surface heparan sulfate proteoglycan attached to the plasma membrane through a glycosylphosphatidylinositol anchor. GPC3 can undergo proteolytic processing, and both its core protein and heparan sulfate chains interact with signaling molecules including Wnt, FGF, and Hedgehog pathway components. GPC3 is strongly expressed during embryonic development but is limited in most normal adult tissues. Re-expression at high levels in hepatocellular carcinoma and selected other solid tumors gives GPC3 a characteristic oncofetal expression pattern. Its tumor-associated expression and cell-surface accessibility have made it an important target for monoclonal antibodies, ADCs, multispecific molecules, and engineered cell therapies. Explore additional information on GPC3 biology and tumor targeting…

DIMA BIOTECH provides human, cynomolgus, and mouse GPC3 recombinant proteins, including constructs representing different extracellular regions, for ELISA, antibody screening, epitope mapping, domain-recognition studies, and cross-species evaluation. Flow cytometry- and IHC-validated monoclonal antibodies, biosimilar reference antibodies, and PE/biotin conjugates support cell-surface detection, tissue analysis, and candidate benchmarking. A GPC3-overexpressing K562 stable cell line enables FACS and cell-binding studies.