CCR5/CD195 Full-Length Nanodisc Proteins, Antibodies and Stable Cell Lines

C-C chemokine receptor type 5 (CCR5), also known as CHEMR13, CMKBR5, CD195, is a class A chemokine GPCR expressed on T cells, macrophages, dendritic cells, and other immune populations. It recognizes chemokines including CCL3, CCL4, and CCL5 and activates Gi-dependent signaling to regulate calcium mobilization, chemotaxis, and inflammatory-cell trafficking. CCR5 is widely known as an important viral entry co-receptor, but its biological relevance extends well beyond infection. The CCR5-chemokine axis participates in immune-cell migration during chronic inflammation, autoimmune disease, tissue repair, and cancer. In the tumor microenvironment, CCR5 can influence immune-cell recruitment, tumor-cell migration, and metastatic behavior, supporting continued interest in receptor antagonism and functional antibody development.

DIMA BIOTECH provides full-length human CCR5 in Synthetic Nanodisc and Strep-tagged formats for native seven-transmembrane receptor screening, SPR/BLI, and binding characterization. A human extracellular/N-terminal protein is available for ELISA and epitope studies. Flow cytometry-validated chimeric monoclonal and reference antibodies, including PE- and biotin-conjugated formats, support cell-surface detection and candidate benchmarking. A CCR5-overexpressing K562 stable cell line provides a standardized platform for FACS, cell-binding assays, and cellular screening. In addition, to accelerate the development of CCR5 biotherapy, DIMA BIOTECH has also prepared a CCR5 target single B cell seed library, from which lead antibody molecules can be obtained in as fast as 28 days; at the same time, we have currently screened out multiple CCR5 lead molecules, and customers can get the molecules for functional evaluation and verification the next day.