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Human CCR5 full length protein-synthetic nanodisc

Price: 10ug$900.00;50 μg $4400.00 ; 100 μg $8000.00

SKU: FLP100100 Category:
Product Data
Package

10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00
Molecular Weight

The human full length CCR5 protein has a MW of 40.3 kDa
Delivery

3-4 weeks
Formulation & Reconstitution

Supplied in nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0)
Target

Storage & Shipping

The product should be stored at -80°C. Please do not repeated freeze-thaw cycles.
Uniprot ID

P51681
Protein Families

Druggable Genome, ES Cell Differentiation/IPS, GPCR, Transmembrane
Protein Pathways

Chemokine signaling pathway, Cytokine-cytokine receptor interaction, Endocytosis
Synonyms

CC-CKR-5; CCCKR5; CCR-5; CD195; CKR-5; CKR5; CMKBR5; IDDM22
Expression Host

HEK293
Description

Human CCR5 full length protein-synthetic nanodisc
Background

This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. An allelic polymorphism in this gene results in both functional and non-functional alleles; the reference genome represents the functional allele. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2015]
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