OX40/TNFRSF4 Recombinant Proteins, Flow Antibodies and Reference Antibodies

OX40, also known as TNFRSF4 or CD134, is a costimulatory member of the tumor necrosis factor receptor superfamily. Its expression is low on resting naïve T cells but increases after antigen-driven activation of CD4+ and CD8+ T cells and is also found on selected regulatory T-cell populations. Interaction with OX40L/TNFSF4 activates TRAF-dependent signaling that enhances T-cell proliferation, survival, cytokine production, and memory formation. The OX40-OX40L pathway therefore helps convert initial antigen recognition into sustained T-cell responses and is studied in tumor immunity, inflammatory disease, and immune regulation. OX40-targeting antibodies may function through agonism, blocking, or Fc-dependent cellular effects, making epitope and receptor-clustering properties important during lead selection.

DIMA BIOTECH provides human and mouse OX40 recombinant ECD proteins in multiple Fc-tagged formats for OX40/OX40L interaction studies, ELISA, SPR/BLI, antibody screening, and cross-species evaluation. Flow cytometry-validated monoclonal antibodies are complemented by a broad panel of reference antibodies and PE/biotin formats for cell-surface detection, receptor-occupancy analysis, and candidate benchmarking. These tools can support both agonistic and blocking antibody programs and downstream T-cell costimulation studies.