TM4SF1 Full-Length Nanodisc/MNP Proteins, ECDs and Antibodies

Transmembrane 4 L Six Family Member 1 (TM4SF1) is a four-pass cell-surface membrane protein of the L6 family with two extracellular loops, including a larger extracellular region that represents an important antibody-accessible epitope space. TM4SF1 is expressed on vascular endothelial cells and participates in cell migration, adhesion, membrane organization, and angiogenic processes. Elevated expression has been reported on both tumor cells and tumor-associated endothelial cells in multiple solid malignancies, giving the target potential relevance to both direct tumor targeting and tumor-vasculature targeting. Its multi-pass topology and relatively compact extracellular regions make preservation of native membrane conformation particularly important for antibody discovery.

DIMA BIOTECH provides full-length human TM4SF1 in Synthetic Nanodisc and MNP formats for native-conformation antibody screening, SPR/BLI, binding kinetics, and specificity assessment. Full ECD and extracellular-loop recombinant proteins provide complementary tools for ELISA, immunization, and epitope studies. Flow cytometry-compatible reference antibodies and PE/biotin-conjugated formats support cell-surface TM4SF1 detection and candidate comparison.