Cynomolgus 4-1BB Ligand Protein, hFc Tag

Name: Cynomolgus 4-1BB Ligand Protein, hFc Tag - DIMA Biotechnology
SKU: PME-C100099
Price: 1085005033000100480.00 USD
Availability: InStock

Price:10μg $85.00; 50μg $330.00 ; 100 μg $500.00

SKU: PME-C100099 Category: ECD Proteins

Datasheet

MSDS

Each batch undergoes strict quality control and contact us to know the details.

Product Data Dima FAQ

Target	4-1BB Ligand
Synonyms	CD137L, TNLG5A, TNFSF9
Description	Recombinant Cynomolgus 4-1BB Ligand protein with N-terminal human Fc tag
Delivery	In Stock
Uniprot ID	XP_015296398.3
Expression Host	HEK293
Tag	N-Human Fc tag
Molecular Characterization	hFc(Glu99-Ala330) 4-1BB Ligand(Arg48-Glu251)
Molecular Weight	The protein has a predicted molecular mass of 47.4 kDa after removal of the signal peptide.
Purity	The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Formulation & Reconstitution	Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
Storage&Shipping	Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Background	The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.[provided by RefSeq, Oct 2008]
Usage	Research use only