| Target | |
|---|---|
| Recommended Dilutions | ELISA 1/5000-10000; Flow Cyt 1/100 |
| Storage & Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Description | Biotinylated Anti-41BB Ligand antibody(DM68), Rabbit mAb |
| Synonyms | 4-1BB Ligand,TNFSF9,CD137L |
| Uniprot ID | P41273 |
| Applications | ELISA, Flow Cyt |
| Host Species | Rabbit |
| IgG type | Rabbit IgG |
| Clonality | Monoclonal |
| Reactivity | Human |
| Purification | Purified from cell culture supernatant by affinity chromatography |
| Buffer | 1XPBS |
| Formulation & Reconstitution | Powder |
| Delivery | 2-3 weeks |
| Usage | Research use only |
| Background | The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction. |
Biotinylated Anti-41BB Ligand antibody(DM68), Rabbit mAb
Price: 10μg $139.00 ; 100 μg $657.00 ; 500 μg $1971.00