Transmembrane proteins are vital cell membrane components involved in transport, signaling, and recognition. Their dysfunction often causes disease, making them major drug targets: over 60% of known drug targets and >90% of antibody drug targets are membrane proteins. Yet, drug development is challenging due to their hydrophobic nature, which complicates soluble expression and native conformation maintenance. Full-length multi-span proteins are usually expressed at low levels, further hindering antigen preparation. Successful antibody development depends on obtaining membrane proteins in their native, functional state. Current antigen strategies and challenges include:
-
- Extracellular domain (ECD) expression – simple, high yield, but may lose conformational epitopes.
- Whole-cell immunization – preserves native conformation and modifications but risks nonspecific antibodies due to complex cell components.
- Full-length proteins – ideal antigens but difficult to express, isolate, and purify.
To overcome these hurdles, DIMA BIOTECH has developed multiple full-length expression platforms. Depending on purification, these include:
-
- Purified platforms: Synthetic Nanodisc, MSP Nanodisc, PeptiNanodisc, Detergent-based.
- Non-purified platforms: MNPs, VLPs, exosomes.
Full Length Transmembrane Proteins
SKU: FLP120515 Target: FLVCR1 Tag: C-Flag&Strep Tag
Expression Host: HEK293
Price: 10 μg $810.00 ; 50 μg $3960.00 ; 100 μg $7200.00
Full Length Transmembrane Proteins
SKU: FLP-M100031 Target: GPR75 Tag: C-Flag Tag
Expression Host: HEK293
Price: 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00
Full Length Transmembrane Proteins
SKU: FLP-C100031 Target: GPR75 Tag: C-Flag Tag
Expression Host: HEK293
Price: 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00
Full Length Transmembrane Proteins
SKU: FLP120514 Target: ReaChR Tag: C-Flag&Strep Tag
Expression Host: HEK293
Price: 10 μg $810.00 ; 50 μg $3960.00 ; 100 μg $7200.00
Full Length Transmembrane Proteins
SKU: FLP120511 Target: DCSTAMP Tag: C-Flag&Strep Tag
Expression Host: HEK293
Price: 10 μg $810.00 ; 50 μg $3960.00 ; 100 μg $7200.00
Full Length Transmembrane Proteins
Biotinylated Human GRIK3 full length protein-synthetic nanodisc
SKU: FLP100845B Target: GRIK3 Tag: C-Flag&Avi Tag
Expression Host: HEK293
Price: 10 μg $990.00 ; 50 μg $4840.00 ; 100 μg $8800.00
Full Length Transmembrane Proteins
Biotinylated Human GRIK2 full length protein-synthetic nanodisc
SKU: FLP100844B Target: GRIK2 Tag: C-Flag&Avi Tag
Expression Host: HEK293
Price: 10 μg $990.00 ; 50 μg $4840.00 ; 100 μg $8800.00
Full Length Transmembrane Proteins
Biotinylated Human GRIK1 full length protein-synthetic nanodisc
SKU: FLP100843B Target: GRIK1 Tag: C-Flag&Avi Tag
Expression Host: HEK293
Price: 10 μg $990.00 ; 50 μg $4840.00 ; 100 μg $8800.00
Full Length Transmembrane Proteins
Biotinylated Human GRIA4 full length protein-synthetic nanodisc
SKU: FLP100842B Target: GRIA4 Tag: C-Flag&Avi Tag
Expression Host: HEK293
Price: 10 μg $990.00 ; 50 μg $4840.00 ; 100 μg $8800.00
Full Length Transmembrane Proteins
Biotinylated Human GRIA3 full length protein-synthetic nanodisc
SKU: FLP100841B Target: GRIA3 Tag: C-Flag&Avi Tag
Expression Host: HEK293
Price: 10 μg $990.00 ; 50 μg $4840.00 ; 100 μg $8800.00
Full Length Transmembrane Proteins
Biotinylated Human GRIA2 full length protein-synthetic nanodisc
SKU: FLP100840B Target: GRIA2 Tag: C-Flag&Avi Tag
Expression Host: HEK293
Price: 10 μg $990.00 ; 50 μg $4840.00 ; 100 μg $8800.00
Full Length Transmembrane Proteins
Biotinylated Human GRIA1 full length protein-synthetic nanodisc
SKU: FLP100839B Target: GRIA1 Tag: C-Flag&Avi Tag
Expression Host: HEK293
Price: 10 μg $990.00 ; 50 μg $4840.00 ; 100 μg $8800.00
Full Length Transmembrane Proteins
Biotinylated Human NMD3B full length protein-synthetic nanodisc
SKU: FLP100838B Target: NMD3B Tag: C-Flag&Avi Tag
Expression Host: HEK293
Price: 10 μg $990.00 ; 50 μg $4840.00 ; 100 μg $8800.00
Full Length Transmembrane Proteins
Biotinylated Human NMD3A full length protein-synthetic nanodisc
SKU: FLP100837B Target: NMD3A Tag: C-Flag&Avi Tag
Expression Host: HEK293
Price: 10 μg $990.00 ; 50 μg $4840.00 ; 100 μg $8800.00
Full Length Transmembrane Proteins
Biotinylated Human NMDE4 full length protein-synthetic nanodisc
SKU: FLP100836B Target: NMDE4 Tag: C-Flag&Avi Tag
Expression Host: HEK293
Price: 10 μg $990.00 ; 50 μg $4840.00 ; 100 μg $8800.00
Full Length Transmembrane Proteins
Biotinylated Human NMDE3 full length protein-synthetic nanodisc
SKU: FLP100835B Target: NMDE3 Tag: C-Flag&Avi Tag
Expression Host: HEK293
Price: 10 μg $990.00 ; 50 μg $4840.00 ; 100 μg $8800.00
Full Length Transmembrane Proteins
Biotinylated Human NMDE2 full length protein-synthetic nanodisc
SKU: FLP100834B Target: NMDE2 Tag: C-Flag&Avi Tag
Expression Host: HEK293
Price: 10 μg $990.00 ; 50 μg $4840.00 ; 100 μg $8800.00
Full Length Transmembrane Proteins
Biotinylated Human NMDZ1 full length protein-synthetic nanodisc
SKU: FLP100833B Target: NMDZ1 Tag: C-Flag&Avi Tag
Expression Host: HEK293
Price: 10 μg $990.00 ; 50 μg $4840.00 ; 100 μg $8800.00
Full Length Transmembrane Proteins
Biotinylated Human GRIK5 full length protein-synthetic nanodisc
SKU: FLP100832B Target: GRIK5 Tag: C-Flag&Avi Tag
Expression Host: HEK293
Price: 10 μg $990.00 ; 50 μg $4840.00 ; 100 μg $8800.00
Full Length Transmembrane Proteins
Biotinylated Human GRIK4 full length protein-synthetic nanodisc
SKU: FLP100831B Target: GRIK4 Tag: C-Flag&Avi Tag
Expression Host: HEK293
Price: 10 μg $990.00 ; 50 μg $4840.00 ; 100 μg $8800.00