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Human CCR8 Protein, hFc Tag

Product Overview
Catalog Number PME101091
Package 10 μg $80.00 ; 50 μg $310.00 ; 100 μg $460.00
Description Recombinant Human CCR8 with C-terminal human Fc tag
Synonyms CC-CKR-8, CCR-8, CDw198, CKRL1, CMKBR8, CMKBRL2, CY6, GPRCY6, TER1
Delivery In Stock
Uniprot ID P51685
Expression Host HEK293
Tag C-Human Fc tag
Molecular Characterization 这里上传图片
Molecular Weight The protein has a predicted molecular mass of 30.1 kDa after removal of the signal peptide.The apparent molecular mass of CCR8-hFc is approximately 35-55 kDa due to glycosylation.
Purity The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Formulation & Reconstitution Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions.
Storage Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).
Usage Research use only
Images

Figure 1. Human CCR8 Protein, hFc Tag on SDS-PAGE under reducing condition.

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Figure 2. ELISA plate pre-coated by 1μg/ml (100μl/well) Human CCR8, hFc Tag (PME101091) can bind Anti-CCR8 Neutralizing antibody (BME100063) in a linear range of 3.2-80 ng/ml.

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Figure 3. Minimal lot-to-lot variability of the recombinant human CCR8 protein (Cat# PME101091) Similar levels of purity and bioactivity of human CCR8 protein (Cat# PME101091) from different purification lots were detected by SDS-PAGE and Coomassie blue staining (Left) and ELISA binding assay (Right).

Background This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are important for the migration of various cell types into the inflammatory sites. This receptor protein preferentially expresses in the thymus. I-309, thymus activation-regulated cytokine (TARC) and macrophage inflammatory protein-1 beta (MIP-1 beta) have been identified as ligands of this receptor. Studies of this receptor and its ligands suggested its role in regulation of monocyte chemotaxis and thymic cell apoptosis. More specifically, this receptor may contribute to the proper positioning of activated T cells within the antigenic challenge sites and specialized areas of lymphoid tissues. This gene is located at the chemokine receptor gene cluster region. [provided by RefSeq, Jul 2008]
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