| Synonyms | Claudin 18.2 |
|---|---|
| Uniprot ID | P56856 |
| Expression Host | HEK293 |
| Description | Human CLDN18.2 full length protein-synthetic nanodisc |
| Molecular Weight | 783 bp |
| Delivery | 3~4 weeks |
| Formulation & Reconstitution | Supplied in nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0) |
| Package | 50 μg $4400.00 ; 100 μg $8000.00 |
| Storage & Shipping | The product should be stored at -80°C. Please do not repeated freeze-thaw cycles. |
| Background | The protein encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jun 2010] |
Human CLDN18.2 full length protein-synthetic nanodisc
Price: 50 μg $4400.00 ; 100 μg $8000.00
Product Data
Images
Figure1. Elisa plates were added with Flag Tag CLDN18.2-Nanodisc (0.2μg/per well) on an anti-Flag monoclonal antibody pre-coated (0.2μg/per well) plate. Serial diluted anti- CLDN18.2 monoclonal antibody (BME100075) solutions were added, washed, and incubated with secondary antibody before Elisa reading. From above data, the EC50 for anti- CLDN18.2 monoclonal antibody binding with CLDN18.2-Nanodisc is 593.6ng/ml.
Figure2. Human CLDN18.2-Nanodisc, Flag Tag on SDS-PAGE