Package | 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00 |
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Molecular Weight | The human full length CMKLR1 protein has a MW of 42.1 kDa |
Delivery | 3-4 weeks |
Formulation & Reconstitution | Supplied in nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0) |
Target | |
Storage & Shipping | The product should be stored at -80°C. Please do not repeated freeze-thaw cycles. |
Uniprot ID | Q99788 |
Protein Families | Druggable Genome, GPCR, Transmembrane |
Protein Pathways | |
Synonyms | CHEMERINR; ChemR23; DEZ; RVER1 |
Expression Host | HEK293 |
Description | Human CMKLR1 full length protein-synthetic nanodisc |
Background | Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism. Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2).[UniProtKB/Swiss-Prot Function] |

Human CMKLR1 full length protein-synthetic nanodisc
Price: 10ug$900.00;50 μg $4400.00 ; 100 μg $8000.00