| Tag | C-Flag Tag |
|---|---|
| Target | |
| Synonyms | PGQTL2 |
| Description | Human GIPR full length protein-synthetic nanodisc |
| Delivery | In Stock |
| Uniprot ID | P48546 |
| Expression Host | HEK293 |
| Protein Families | Druggable Genome, GPCR, Transmembrane |
| Protein Pathways | Neuroactive ligand-receptor interaction |
| Molecular Weight | The human full length GIPR protein has a MW of 53.2 kDa |
| Formulation & Reconstitution | Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions. Do not use solvents with a pH below 6.5 or those containing high concentrations of divalent metal ions (greater than 5 mM) in subsequent experiments. |
| Storage & Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Background | A G-protein coupled receptor for gastric inhibitory polypeptide (GIP), which was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release in the presence of elevated glucose. Mice lacking this gene exhibit higher blood glucose levels with impaired initial insulin response after oral glucose load. Defect in this gene thus may contribute to the pathogenesis of diabetes. |
| Usage | Research use only |
| Conjugate | Unconjugated |
Human GIPR full length protein-synthetic nanodisc
Price: 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00
Product Data Dima FAQ
Images Dima FAQ
Figure 1. Elisa plates were pre-coated with Flag Tag GIPR-Nanodisc (0.2μg/per well). Serial diluted anti-GIPR monoclonal antibody (BME100209) solutions were added, washed, and incubated with secondary antibody before Elisa reading. From above data, the EC50 for anti-GIPR monoclonal antibody binding with GIPR-Nanodisc is 862.5ng/ml.
Figure 2. Human GIPR-Nanodisc, Flag Tag on SDS-PAGE
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