Tag | C-Flag Tag |
---|---|
Target | |
Synonyms | DOP, DOR, DOR1, OPRD |
Description | Human OPRD full length protein-synthetic nanodisc |
Delivery | 6~8weeks |
Uniprot ID | P41143 |
Expression Host | HEK293 |
Protein Families | Transmembrane,Druggable Genome, |
Protein Pathways | GPCRDB Class A Rhodopsin-like,Peptide GPCRs,Autoimmune & Inflammatory Response,G-Protein Coupled Receptors Signaling Pathway,Na2+/NF-AT Signaling Pathways, |
Molecular Weight | The human full length OPRD protein has a MW of 40.4kDa |
Formulation & Reconstitution | Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions. Do not use solvents with pH lower than 6.5 in subsequent experiments. |
Storage & Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
Background | G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine.[UniProtKB/Swiss-Prot Function] |
Usage | Research use only |
Human OPRD full length protein-synthetic nanodisc
Price: 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00
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