| Tag | C-Flag&Strep Tag |
|---|---|
| Target | |
| Synonyms | BFIC3, BFIS3, BFNIS, DEE11, EA9, EIEE11, HBA, HBSCI, HBSCII, NAC2, Na(v)1.2, Nav1.2, SCN2A1, SCN2A2 |
| Description | Human SCN2A-Strep full length protein-synthetic nanodisc |
| Delivery | 6~8weeks |
| Uniprot ID | Q99250 |
| Expression Host | HEK293 |
| Protein Families | Ion Channels: Sodium |
| Protein Pathways | N/A |
| Molecular Weight | The human full length SCN2A-Strep protein has a MW of 228 kDa |
| Formulation & Reconstitution | Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
| Storage & Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Background | Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with four repeat domains, each of which is composed of six membrane-spanning segments, and one or more regulatory beta subunits. Voltage-gated sodium channels function in the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family. Allelic variants of this gene are associated with seizure disorders and autism spectrum disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016] |
| Usage | Research use only |
| Conjugate | Unconjugated |
Human SCN2A-Strep full length protein-synthetic nanodisc
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