CD27/TNFRSF7 Proteins, Antibodies and Stable Cell Lines

CD27 (TNFRSF7) is a costimulatory receptor of the TNF receptor superfamily expressed on T cells, selected B-cell populations, NK cells, and other hematopoietic subsets. Its ligand CD70 is transiently induced on activated lymphocytes and antigen-presenting cells. CD27-CD70 signaling activates TRAF-dependent pathways that promote T-cell expansion, survival, effector differentiation, and memory formation and can also influence B- and NK-cell function. Because persistent CD70 expression can occur in selected tumors, the CD27-CD70 pathway has relevance to both immune costimulation and tumor immune regulation. Antibody programs may seek agonistic, regulatory, or cell-selective activity, making cellular functional assays particularly important.

DIMA BIOTECH provides multiple CD27 recombinant ECD proteins for CD27-CD70 interaction studies, ELISA, SPR/BLI, antibody screening, and cross-species evaluation. Flow cytometry-validated monoclonal and reference antibodies support cell-surface detection and candidate comparison. CD27-overexpressing stable cell lines provide standardized platforms for FACS, cell-binding, and functional antibody screening. This combination enables CD27 programs to progress from biochemical binding characterization to cellular costimulatory evaluation.