SSTR2 Full-Length Membrane Proteins, Nanodiscs, Antibodies and Stable Cell Lines

Somatostatin receptor 2 (SSTR2), also known as SS2R, is one of five somatostatin-receptor subtypes and a class A seven-transmembrane GPCR. Binding of somatostatin primarily activates Gi/o proteins, suppressing adenylyl cyclase while modulating calcium and potassium channels and additional downstream pathways. Through these mechanisms, SSTR2 regulates hormone secretion, neurotransmitter release, proliferation, and apoptosis. The receptor is expressed in the central nervous and endocrine systems and can remain highly expressed on multiple neuroendocrine tumors and selected pituitary tumors. Its stable and accessible surface expression has made SSTR2 important not only for receptor pharmacology but also for molecular imaging, radioligands, peptide-drug conjugates, antibodies, and other targeted-delivery strategies.

DIMA BIOTECH provides full-length human SSTR2 in Synthetic Nanodisc, MNP, and cell-free Nanodisc/detergent formats. These reagents support native-conformation antibody screening, SPR/BLI, receptor-ligand binding, and specificity studies. An extracellular/N-terminal protein provides an additional tool for ELISA and epitope analysis. Flow cytometry-validated monoclonal and reference antibodies support cell-surface detection and candidate comparison, while an SSTR2-overexpressing stable cell line enables FACS and cell-binding studies. At the same time, we can also provide systematic services, including protein/antibody customization services, antibody humanization, antibody affinity maturation, stable cell lines, etc. In addition, we have established a B cell seed bank targeting SSTR2, which can screen out the lead antibody molecules required by customers in just 20 days.