| Package | 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00 |
|---|---|
| Molecular Weight | The human full length C5AR1 protein has a MW of 39.3 kDa |
| Delivery | 3-4 weeks |
| Formulation & Reconstitution | Supplied in nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0) |
| Target | |
| Storage & Shipping | The product should be stored at -80°C. Please do not repeated freeze-thaw cycles. |
| Uniprot ID | P21730 |
| Protein Families | Druggable Genome, GPCR, Transmembrane |
| Protein Pathways | Complement and coagulation cascades, Neuroactive ligand-receptor interaction |
| Synonyms | C5A; C5AR; C5R1; CD88 |
| Expression Host | HEK293 |
| Description | Human C5AR1 full length protein-synthetic nanodisc |
| Background | Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a (PubMed:1847994, PubMed:8182049, PubMed:7622471, PubMed:9553099, PubMed:10636859, PubMed:15153520, PubMed:29300009). The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events (PubMed:8182049, PubMed:7622471, PubMed:9553099). Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (PubMed:10636859, PubMed:15153520).[UniProtKB/Swiss-Prot Function] |
Human C5AR1 full length protein-synthetic nanodisc
Price: 10ug$900.00;50 μg $4400.00 ; 100 μg $8000.00