CD37/TSPAN26 Full-Length Nanodisc Proteins, Antibodies and Stable Cell Lines

CD37, also known as TSPAN26, is a four-pass tetraspanin membrane protein with a small and a large extracellular loop. It is highly expressed on mature B cells and is also present on selected T-cell and myeloid populations. As part of the tetraspanin web, CD37 associates with integrins, other tetraspanins, and signaling proteins in specialized membrane microdomains, thereby influencing cellular adhesion, migration, survival, and immune signaling. CD37 remains highly expressed in several B-cell malignancies, making it an attractive target for antibody and ADC research. Because its extracellular regions are relatively small and structurally constrained by the four transmembrane segments, full-length membrane presentation is useful for identifying conformation-dependent antibodies.

DIMA BIOTECH provides full-length human CD37 in Synthetic Nanodisc and Strep-tagged formats for native-conformation antibody discovery, SPR/BLI, and binding studies. Human CD37 ECD protein provides an additional antigen for ELISA, immunization, and initial antibody screening. A flow cytometry-validated rabbit monoclonal antibody, reference antibodies, and biotinylated formats support cell-surface detection and candidate benchmarking. A CD37-overexpressing 293T stable cell line enables FACS, cell-binding assays, and cellular screening. In addition, to accelerate the development of CD37 biotherapy, DIMA BIOTECH has also prepared a single B cell seed library of CD37, from which lead antibody molecules can be obtained in as fast as 28 days; at the same time, we have currently screened out multiple CD37 IgG sequence ready to out-liscensing, and customers can get the molecules for functional evaluation and verification the next day.