BAFF/TNFSF13B Recombinant Proteins and Antibodies

B-cell Activating Factor (BAFF), encoded by TNFSF13B and also known as BLyS or CD257, is a member of the tumor necrosis factor ligand superfamily and a central regulator of B-cell survival and maturation. Other immunologically important members of this ligand family include APRIL/TNFSF13, CD40L/TNFSF5, OX40L/TNFSF4, 4-1BBL/TNFSF9, and CD70/TNFSF7. BAFF interacts with three major receptors: BAFF-R/TNFRSF13C, TACI/TNFRSF13B, and BCMA/TNFRSF17. BAFF-R is particularly important for mature B-cell homeostasis, whereas TACI and BCMA also recognize APRIL and contribute to plasma-cell survival and immunoglobulin production. Excessive BAFF signaling can promote persistence of autoreactive B cells and abnormal antibody responses, linking the pathway to systemic autoimmune disease. BAFF-BCMA signaling is also highly relevant to plasma-cell biology and B-cell malignancy research.

DIMA BIOTECH provides human and mouse BAFF recombinant proteins in multiple Fc- and His-tagged formats for BAFF-receptor interaction studies, ELISA, SPR/BLI, antibody screening, and cross-species evaluation. Rabbit monoclonal antibodies and multiple reference antibodies, including biotinylated formats, support BAFF detection, candidate-neutralizing-antibody benchmarking, and assay development.