EGFR Antibodies, Proteins & Stable Cell Lines

EGFR, or Epidermal Growth Factor Receptor, also known as ERBB1, is a prototypical member of the ERBB receptor tyrosine kinase family. Binding of ligands such as EGF and TGF-α induces receptor dimerization and activation of the intracellular kinase domain, leading to downstream signaling through pathways including RAS/MAPK, PI3K/AKT, and JAK/STAT. These pathways regulate essential cellular processes such as proliferation, survival, differentiation, and migration. EGFR overexpression, amplification, or mutation is found in multiple solid tumors, making it one of the most extensively studied targets in oncology. In addition to receptor-blocking strategies, EGFR is also widely investigated in ADC, multispecific antibody, and engineered cell-therapy programs. Because the EGFR extracellular region contains multiple structurally distinct domains, antibody epitope location can strongly influence receptor blocking, conformational effects, internalization, and downstream biological activity.

DIMA BIOTECH provides full-length EGFR ECD and multiple domain-specific recombinant proteins, rabbit monoclonal antibodies, a broad panel of biosimilar reference antibodies, PE- and biotin-conjugated products, and an EGFR-overexpressing stable cell line. Domain proteins support ELISA, antibody screening, epitope mapping, competitive binding, and domain-recognition studies. Flow antibodies and stable cells enable cell-surface detection, FACS, cell-binding assays, and candidate comparison, providing a versatile toolkit for EGFR antibody discovery and functional characterization.