AXL Recombinant Proteins, Antibodies and Research Tools

AXL, also known as Ark, Ufo and Tyro-7, is a member of the TAM family of receptor tyrosine kinases, with GAS6 serving as one of its major ligands. AXL signaling is involved in cell survival, proliferation, migration, and immune regulation. Aberrant AXL expression or activation has been observed in multiple solid tumors and has been associated with tumor progression, metastasis, and therapeutic resistance, making AXL an important target for antibody, ADC, cell therapy, and other targeted therapeutic research. More about the mechanism of action and signaling pathway of AXL >>

DIMA BIOTECH offers a comprehensive portfolio of AXL research tools, including human, cynomolgus, and mouse AXL ECD proteins, recombinant proteins covering different extracellular regions, rabbit monoclonal antibodies, biosimilar reference antibodies, and PE- and biotin-conjugated antibodies. Recombinant AXL proteins with different tags and extracellular regions can support ELISA, antibody screening, binding assays, affinity characterization, epitope studies, and cross-species reactivity evaluation. Flow cytometry-validated antibodies and reference antibodies can be used for cell-surface AXL detection, candidate screening, and assay development, while PE-conjugated antibodies enable direct flow cytometry analysis.

Beyond research reagents, DIMA BIOTECH has established a single B-cell resource for AXL antibody discovery and can further support lead generation, humanization, affinity maturation, and PTM risk-site optimization, providing an integrated workflow from target validation to antibody engineering.