CCR6/CD196 Full-Length Nanodisc Proteins and Flow Antibodies

C-C chemokine receptor 6 (CCR6), also known as CD196, CKRL3, CMKBR6, GPR29 or STRL22, is a class A seven-transmembrane chemokine receptor whose principal ligand is CCL20. It belongs to the CC chemokine receptor family, which also includes CCR1, CCR2, CCR4, CCR5, CCR7, and CCR8. CCR6 is expressed on dendritic cells, B cells, subsets of memory T cells, and particularly Th17 cells. The CCL20-CCR6 axis regulates trafficking to mucosal, cutaneous, and inflammatory tissues and contributes to intestinal and skin immune homeostasis. Dysregulated signaling has been associated with chronic inflammation, autoimmune disease, and altered immune-cell recruitment within tumors. Like other chemokine GPCRs, CCR6 contains conformation-dependent extracellular epitopes whose presentation is strongly influenced by the membrane environment.

DIMA BIOTECH provides full-length human CCR6 in Synthetic Nanodisc and membrane nanoparticle formats, including a biotinylated Synthetic Nanodisc protein. These products support native-conformation antibody screening, SPR/BLI, binding kinetics, and specificity analysis. Human and mouse extracellular-domain proteins provide complementary tools for ELISA, immunization, epitope studies, and cross-species evaluation. A flow cytometry-validated chimeric monoclonal antibody is available in unconjugated, PE-conjugated, and biotinylated formats for cell-surface detection and candidate benchmarking. In addition, we have established a B cell seed bank targeting CCR6, which can screen out the lead antibody molecules required by customers in just 20 days.