Accelerating GPRC5D Therapy: Proteins, mAbs and CAR-T
GPRC5D plays a pivotal role in cancer and immunology research, garnering significant industry attention. At DIMA Biotechnology, we provide essential tools for exploring this promising target. Our offerings include functional active proteins and specialized antibodies, with a particular focus on GPRC5D CAR-T molecules, which have progressed from leads to Investigator-Initiated Trial (IIT) clinical trial stages in collaboration with our partners. Preliminary data from ongoing clinical trials showcase remarkable clinical efficacy, particularly in treating RRMM patients. Our proprietary technology platforms streamline drug discovery processes, offering comprehensive support to expedite therapeutic research and development.
GPRC5D Background
In recent developments, LaNova’s LM-305, an ADC targeting GPRC5D, secured an exclusive global license with AstraZeneca, resulting in an immediate payment of $55 million and the potential for milestone payments totaling $545 million. Concurrently, OriCell Therapeutics introduced OriCAR-017, marking China’s first CAR-T cell therapy designed to target GPRC5D. Additionally, Janssen’s talquetamab, a GPRC5D/CD3 bispecific antibody, displayed promising results in treating RRMM patients, with an anticipated U.S. launch as early as 2024. These advancements underscore the dynamic landscape of GPRC5D-targeted drugs and their potential to revolutionize the pharmaceutical industry.
GPRC5D Products
Biosimilar reference antibodies
SKU: BME100187 Target: GPRC5D
Price: 50μg $80.00 ; 100 μg $160.00
Full Length Transmembrane Proteins
SKU: FLP100011 Target: GPRC5D
Price: 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00
Full Length Transmembrane Proteins
SKU: FLP100010 Target: GPRC5D
Price: 50 μg $1200.00 ; 100 μg $1600.00
ECD Proteins
SKU: PME100559P Target: GPRC5D
Price: 25test $340.00
DimAb monoclonal antibodies
SKU: DME100062B Target: GPRC5D
Price: 10μg $139.00 ; 100 μg $657.00 ; 500 μg $1971.00
DimAb monoclonal antibodies
SKU: DME100060B Target: GPRC5D
Price: 10μg $139.00 ; 100 μg $657.00 ; 500 μg $1971.00
DimAb monoclonal antibodies
SKU: DME100091P Target: GPRC5D
100 test $550.00
DimAb monoclonal antibodies
SKU: DME100089B Target: GPRC5D
Price: 10μg $139.00 ; 100 μg $657.00 ; 500 μg $1971.00
DimAb monoclonal antibodies
SKU: DME100091B Target: GPRC5D
Price: 10μg $139.00 ; 100 μg $657.00 ; 500 μg $1971.00
DimAb monoclonal antibodies
SKU: DME100090B Target: GPRC5D
Price: 10μg $139.00 ; 100 μg $657.00 ; 500 μg $1971.00
DimAb monoclonal antibodies
SKU: DME100061B Target: GPRC5D
Price: 10μg $139.00 ; 100 μg $657.00 ; 500 μg $1971.00
DimAb monoclonal antibodies
SKU: DME100091 Target: GPRC5D
Price: 10μg $99.00 ; 100 μg $438.00 ; 500 μg $1314.00
DimAb monoclonal antibodies
SKU: DME100090 Target: GPRC5D
Price: 10μg $99.00 ; 100 μg $438.00 ; 500 μg $1314.00
DimAb monoclonal antibodies
SKU: DME100089 Target: GPRC5D
Price: 10μg $99.00 ; 100 μg $438.00 ; 500 μg $1314.00
DimAb monoclonal antibodies
SKU: DME100062 Target: GPRC5D
Price: 10μg $99.00 ; 100 μg $438.00 ; 500 μg $1314.00
DimAb monoclonal antibodies
SKU: DME100061 Target: GPRC5D
Price: 10μg $99.00 ; 100 μg $438.00 ; 500 μg $1314.00
DimAb monoclonal antibodies
SKU: DME100060 Target: GPRC5D
Price: 10μg $99.00 ; 100 μg $438.00 ; 500 μg $1314.00
Biosimilar reference antibodies
SKU: BME100072 Target: GPRC5D
Price: 50μg $80.00 ; 100 μg $160.00
ECD Proteins
SKU: PME100677 Target: GPRC5D
Price: 10μg $74.00 ; 50μg $296.00 ; 100 μg $444.00
ECD Proteins
SKU: PME100561 Target: GPRC5D
Price: 10μg $65.00 ; 50μg $259.00 ; 100 μg $389.00