CDH17 Antibody and Cell Assay Selection Guide Domain, Conformation, and Cross-Species Considerations
Cadherin-17 (CDH17) is a non-classical calcium-dependent adhesion protein predominantly expressed in the intestinal epithelium and highly upregulated in multiple gastrointestinal tumors. Due to its tumor-specific expression, CDH17 has become a promising therapeutic target. Current CDH17-targeting strategies include: Antibody-drug conjugates (ADC), Cell therapies (CAR-T/CAR-NK), Monoclonal, bispecific, or trispecific antibodies.