Product Targets:
| 2B4 | 4-1BB | 4-1BB-L | SIRPα |
| B7-H3 | BCMA | CD123 | CD48 |
| CD138 | CD22 | CD27 | GITR Ligand |
| CD28 | CD38 | CD47 | CS1 |
| GPRC5D | CTLA-4 | MSLN | TROP2 |
| GITR | TIM3 | B7-2 | PSCA |
| NKp30 | BTN3A1 | DNAM1 | B7-H2 |
| CD40 |
DIMA mAbs Rabbit Monoclonal Antibodies
Compared with other animals, rabbits have a unique process of B cell development and are farther apart than rodents and humans. In addition, rabbit B cells have a dual affinity maturation mechanism, including gene conversion and SHM (somatic hypermutation). At the same time, the protein structure of rabbit IgG is different from that of mouse IgG, which is reflected in that it has only one subtype of IgG and its CDR3 region is longer than mouse CDR3. These differences make rabbit produce monoclonal antibodies with higher affinity and specificity.
DIMA Biotechnology Ltd. is a biotech company focusing on preclinical R&D products and services for druggable targets. We plan to complete the preparation of lead antibody molecules for all druggable targets in the next 3-5 years. Currently, we have developed over 1000 monoclonal antibodies for cancer targets. Scientists can skip the tedious steps of antibody development and screening. They can have more time to study the biological mechanism and developability of drug targets, thus accelerating the process of new drug R&D.
DIMA’s rabbit monoclonal antibodies are developed using our own proprietary DIMA monoclonal antibody development platform. All our antibodies are raised against the potential diagnostic, prognostic and therapeutic targets. We used functional proteins as antigens and verified the antibodies with various applications and protein samples. Most of our monoclonal antibodies show comparable or better specificities and affinities comparing to the reference antibodies. In addition to the specificity and affinity, DIMA’s recombinant monoclonal antibodies also show high level of batch-to-batch consistency, because our single B cell cloning technology can directly isolate IgG gene from positive rabbit B cells, which significantly lower risk of the loss of hybridoma cells.
Product Advantage:
High affinity and high specificity
Figure 1. A) Flow cytometry data of serially titrated Rabbit anti-SIRPα monoclonal antibody (clone: DM8). The Y-axis represents the mean fluorescence intensity (MFI) while the X-axis represents the concentration of IgG used. B) Competition assay demonstrating DM8 blockade of CD47 binding to THP-1 cells. IC50=30.88ng/ml.
Multiple candidate clones of a single target showed high selectivity
Figure 2. Affinity ranking of different Rabbit anti-CS1 mAb clones by titration of different concentration onto Raji cells. The Y-axis represents the mean fluorescence intensity (MFI) while the X-axis represents the concentration of IgG used.
The List of DIMA BIOTECH's Rabbit MAbs
Monoclonal antibodies
SKU: DMC100725 Target: CD45
Application: IHC
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Monoclonal antibodies
SKU: DMC100741 Target: SELPLG
Application: IHC
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Monoclonal antibodies
SKU: DMC100832 Target: ADAM9
Application: IHC
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Monoclonal antibodies
SKU: DME101025B Target: Dxd
Application: ELISA
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DME101007B Target: MMAE
Application: ELISA
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DME101006B Target: MMAE
Application: ELISA
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DMC100682B Target: CD166
Application: Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DMC100492B Target: GPR75
Application: Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DMC100478B Target: GPR87
Application: Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DMC100368B Target: GPR75
Application: Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DME100204B Target: CD73
Application: ELISA; Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DME100191B Target: CD70
Application: ELISA; Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DME100188B Target: B7-H4
Application: ELISA; Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DMC100868 Target: AXL
Application: WB
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Monoclonal antibodies
SKU: DMC100228 Target: ROR1
Application: WB
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Monoclonal antibodies
SKU: DME101001 Target: Trop2
Application: WB
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Monoclonal antibodies
SKU: DME100853 Target: FCRL5
Application: IHC
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Monoclonal antibodies
SKU: DME100580 Target: HER3
Application: IHC; Flow Cyt
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Monoclonal antibodies
SKU: DME100433 Target: HER3
Application: WB
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Monoclonal antibodies
SKU: DME201009 Target: CD7
Application: WB
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Monoclonal antibodies
SKU: DME100012 Target: CD22
Application: WB; Flow Cyt
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Monoclonal antibodies
SKU: DMC100908 Target: GPC3
Application: IHC
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Monoclonal antibodies
SKU: DMC100875 Target: PDL1
Application: WB
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Monoclonal antibodies
SKU: DMC100804 Target: CD19
Application: WB
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Monoclonal antibodies
SKU: DMC100637 Target: CDH17
Application: WB; Flow Cyt
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Monoclonal antibodies
SKU: DMC100608 Target: MICA
Application: WB; Flow Cyt
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Monoclonal antibodies
SKU: DMC100585 Target: FOLR1
Application: WB
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Monoclonal antibodies
SKU: DMC100508 Target: GUCY2C
Application: WB
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Monoclonal antibodies
SKU: DMC100120 Target: CEACAM5
Application: WB
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Monoclonal antibodies
SKU: DME201007 Target: Mouse IgG
Application: ELISA
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Monoclonal antibodies
SKU: DME201006 Target: Mouse IgG
Application: ELISA
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Monoclonal antibodies
SKU: DME201005 Target: Mouse IgG
Application: ELISA
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00