Product Targets:
| 2B4 | 4-1BB | 4-1BB-L | SIRPα |
| B7-H3 | BCMA | CD123 | CD48 |
| CD138 | CD22 | CD27 | GITR Ligand |
| CD28 | CD38 | CD47 | CS1 |
| GPRC5D | CTLA-4 | MSLN | TROP2 |
| GITR | TIM3 | B7-2 | PSCA |
| NKp30 | BTN3A1 | DNAM1 | B7-H2 |
| CD40 |
DIMA mAbs Rabbit Monoclonal Antibodies
Compared with other animals, rabbits have a unique process of B cell development and are farther apart than rodents and humans. In addition, rabbit B cells have a dual affinity maturation mechanism, including gene conversion and SHM (somatic hypermutation). At the same time, the protein structure of rabbit IgG is different from that of mouse IgG, which is reflected in that it has only one subtype of IgG and its CDR3 region is longer than mouse CDR3. These differences make rabbit produce monoclonal antibodies with higher affinity and specificity.
DIMA Biotechnology Ltd. is a biotech company focusing on preclinical R&D products and services for druggable targets. We plan to complete the preparation of lead antibody molecules for all druggable targets in the next 3-5 years. Currently, we have developed over 1000 monoclonal antibodies for cancer targets. Scientists can skip the tedious steps of antibody development and screening. They can have more time to study the biological mechanism and developability of drug targets, thus accelerating the process of new drug R&D.
DIMA’s rabbit monoclonal antibodies are developed using our own proprietary DIMA monoclonal antibody development platform. All our antibodies are raised against the potential diagnostic, prognostic and therapeutic targets. We used functional proteins as antigens and verified the antibodies with various applications and protein samples. Most of our monoclonal antibodies show comparable or better specificities and affinities comparing to the reference antibodies. In addition to the specificity and affinity, DIMA’s recombinant monoclonal antibodies also show high level of batch-to-batch consistency, because our single B cell cloning technology can directly isolate IgG gene from positive rabbit B cells, which significantly lower risk of the loss of hybridoma cells.
Product Advantage:
High affinity and high specificity
Figure 1. A) Flow cytometry data of serially titrated Rabbit anti-SIRPα monoclonal antibody (clone: DM8). The Y-axis represents the mean fluorescence intensity (MFI) while the X-axis represents the concentration of IgG used. B) Competition assay demonstrating DM8 blockade of CD47 binding to THP-1 cells. IC50=30.88ng/ml.
Multiple candidate clones of a single target showed high selectivity
Figure 2. Affinity ranking of different Rabbit anti-CS1 mAb clones by titration of different concentration onto Raji cells. The Y-axis represents the mean fluorescence intensity (MFI) while the X-axis represents the concentration of IgG used.
The List of DIMA BIOTECH's Rabbit MAbs
Monoclonal antibodies
SKU: DME101021 Target: CL2A
Application: ELISA
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Monoclonal antibodies
SKU: DME101020 Target: SN38
Application: ELISA
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Monoclonal antibodies
SKU: DME100791 Target: NEFL
Application: ELISA
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Monoclonal antibodies
SKU: DME100790 Target: NEFL
Application: ELISA
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Monoclonal antibodies
SKU: DME100789 Target: NEFL
Application: ELISA
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Monoclonal antibodies
SKU: DME100787 Target: NEFL
Application: ELISA
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Monoclonal antibodies
SKU: DME100788 Target: NEFL
Application: ELISA
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Monoclonal antibodies
SKU: DME100786 Target: NEFL
Application: ELISA
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Monoclonal antibodies
SKU: DME100800 Target: GFAP
Application: ELISA
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Monoclonal antibodies
SKU: DME100798 Target: GFAP
Application: ELISA
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Monoclonal antibodies
SKU: DME100264 Target: GFAP
Application: ELISA
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Monoclonal antibodies
SKU: DME100263 Target: GFAP
Application: ELISA
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Monoclonal antibodies
SKU: DME100801 Target: GFAP
Application: ELISA
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Monoclonal antibodies
SKU: DME100803 Target: GFAP
Application: ELISA
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Monoclonal antibodies
SKU: DME100266 Target: UCHL1
Application: ELISA
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Monoclonal antibodies
SKU: DME100265 Target: UCHL1
Application: ELISA
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Monoclonal antibodies
SKU: DME100843 Target: UCHL1
Application: ELISA; WB
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Monoclonal antibodies
SKU: DMC100253 Target: ROR1
Application: Flow Cyt
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Monoclonal antibodies
SKU: DMC100382 Target: CSF1R
Application: Flow Cyt
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Monoclonal antibodies
SKU: DMC101096 Target: SEZ6
Application: Flow Cyt
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Monoclonal antibodies
SKU: DMC101095 Target: TFRC
Application: Flow Cyt
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Monoclonal antibodies
SKU: DMC101094 Target: B7H7
Application: Flow Cyt
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Monoclonal antibodies
SKU: DMC101093 Target: CD147
Application: Flow Cyt
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Monoclonal antibodies
SKU: DMC101092 Target: PGLYRP1
Application: Flow Cyt
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Monoclonal antibodies
SKU: DMC101091 Target: PVRIG
Application: ELISA, Flow Cyt
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Monoclonal antibodies
SKU: DMC101085 Target: CD3E
Application: Flow Cyt
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Monoclonal antibodies
SKU: DMC101089 Target: DLL3
Application: Flow Cyt
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Monoclonal antibodies
SKU: DMC100345 Target: CD93
Application: Flow Cyt
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Monoclonal antibodies
SKU: DMC101054 Target: THEMIS
Application: ELISA
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Monoclonal antibodies
SKU: DMC101041 Target: CDH3
Application: Flow Cyt
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Monoclonal antibodies
SKU: DMC101040 Target: EGFRVIII
Application: Flow Cyt
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Monoclonal antibodies
SKU: DMC101039 Target: CLEC4C
Application: Flow Cyt
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00