Product Targets:
| 2B4 | 4-1BB | 4-1BB-L | SIRPα |
| B7-H3 | BCMA | CD123 | CD48 |
| CD138 | CD22 | CD27 | GITR Ligand |
| CD28 | CD38 | CD47 | CS1 |
| GPRC5D | CTLA-4 | MSLN | TROP2 |
| GITR | TIM3 | B7-2 | PSCA |
| NKp30 | BTN3A1 | DNAM1 | B7-H2 |
| CD40 |
DIMA mAbs Rabbit Monoclonal Antibodies
Compared with other animals, rabbits have a unique process of B cell development and are farther apart than rodents and humans. In addition, rabbit B cells have a dual affinity maturation mechanism, including gene conversion and SHM (somatic hypermutation). At the same time, the protein structure of rabbit IgG is different from that of mouse IgG, which is reflected in that it has only one subtype of IgG and its CDR3 region is longer than mouse CDR3. These differences make rabbit produce monoclonal antibodies with higher affinity and specificity.
DIMA Biotechnology Ltd. is a biotech company focusing on preclinical R&D products and services for druggable targets. We plan to complete the preparation of lead antibody molecules for all druggable targets in the next 3-5 years. Currently, we have developed over 1000 monoclonal antibodies for cancer targets. Scientists can skip the tedious steps of antibody development and screening. They can have more time to study the biological mechanism and developability of drug targets, thus accelerating the process of new drug R&D.
DIMA’s rabbit monoclonal antibodies are developed using our own proprietary DIMA monoclonal antibody development platform. All our antibodies are raised against the potential diagnostic, prognostic and therapeutic targets. We used functional proteins as antigens and verified the antibodies with various applications and protein samples. Most of our monoclonal antibodies show comparable or better specificities and affinities comparing to the reference antibodies. In addition to the specificity and affinity, DIMA’s recombinant monoclonal antibodies also show high level of batch-to-batch consistency, because our single B cell cloning technology can directly isolate IgG gene from positive rabbit B cells, which significantly lower risk of the loss of hybridoma cells.
Product Advantage:
High affinity and high specificity
Figure 1. A) Flow cytometry data of serially titrated Rabbit anti-SIRPα monoclonal antibody (clone: DM8). The Y-axis represents the mean fluorescence intensity (MFI) while the X-axis represents the concentration of IgG used. B) Competition assay demonstrating DM8 blockade of CD47 binding to THP-1 cells. IC50=30.88ng/ml.
Multiple candidate clones of a single target showed high selectivity
Figure 2. Affinity ranking of different Rabbit anti-CS1 mAb clones by titration of different concentration onto Raji cells. The Y-axis represents the mean fluorescence intensity (MFI) while the X-axis represents the concentration of IgG used.
The List of DIMA BIOTECH's Rabbit MAbs
Monoclonal antibodies
SKU: DME201004 Target: Mouse IgG
Application: ELISA
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Monoclonal antibodies
SKU: DME201003 Target: Mouse IgG
Application: ELISA
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Monoclonal antibodies
SKU: DME201002 Target: Mouse IgG
Application: ELISA
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Monoclonal antibodies
SKU: DME201001 Target: Mouse IgG
Application: ELISA
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Monoclonal antibodies
SKU: DME101018 Target: Human IgG
Application: ELISA
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Monoclonal antibodies
SKU: DME101036 Target: Human IgG
Application: ELISA
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Monoclonal antibodies
SKU: DME101035 Target: Human IgG
Application: ELISA
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Monoclonal antibodies
SKU: DME101037 Target: Human IgG
Application: ELISA
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Monoclonal antibodies
SKU: DME101034 Target: Human IgG
Application: ELISA
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Monoclonal antibodies
SKU: DME101033 Target: Human IgG
Application: ELISA
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Monoclonal antibodies
SKU: DME101032 Target: Human IgG
Application: ELISA
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Monoclonal antibodies
SKU: DME101031 Target: Human IgG
Application: ELISA
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Monoclonal antibodies
SKU: DME101030 Target: Human IgG
Application: ELISA
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Monoclonal antibodies
SKU: DME101029 Target: Human IgG
Application: ELISA
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Monoclonal antibodies
SKU: DME101028 Target: Human IgG
Application: ELISA
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Monoclonal antibodies
SKU: DME101046 Target: EGFP
Application: WB, IP
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Monoclonal antibodies
SKU: DMC101152 Target: GPNMB
Application: Flow Cyt
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Monoclonal antibodies
SKU: DMC101150 Target: CD19
Application: Flow Cyt
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Monoclonal antibodies
SKU: DMC101114 Target: CD205
Application: Flow Cyt
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Monoclonal antibodies
SKU: DMC101113 Target: TIM-1
Application: Flow Cyt
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Monoclonal antibodies
SKU: DMC101151 Target: ADAMTS1
Application: Flow Cyt
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Monoclonal antibodies
SKU: DMC101112 Target: NCR1
Application: Flow Cyt
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Monoclonal antibodies
SKU: DMC101110 Target: FLT3
Application: Flow Cyt
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Monoclonal antibodies
SKU: DMC101149 Target: ANPEP
Application: Flow Cyt
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Monoclonal antibodies
SKU: DMC101111 Target: FZD4
Application: Flow Cyt
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Monoclonal antibodies
SKU: DME100061B Target: GPRC5D
Application: ELISA,IHC
Price: 10μg $139.00 ; 100 μg $657.00 ; 500 μg $1971.00
Monoclonal antibodies
SKU: DME101027 Target: Dxd
Application: ELISA
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Monoclonal antibodies
SKU: DME101026 Target: Dxd
Application: ELISA
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Monoclonal antibodies
SKU: DME101025 Target: Dxd
Application: ELISA
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Monoclonal antibodies
SKU: DME101024 Target: Dxd
Application: ELISA
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Monoclonal antibodies
SKU: DME101023 Target: CL2A
Application: ELISA
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Monoclonal antibodies
SKU: DME101022 Target: CL2A
Application: ELISA
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00