Extracellular Domain Protein (ECD)

DIMA BIOTECH offers over 1000 ECD proteins covering more than 600 single pass membrane protein targets. All the proteins were made using HEK293 mammalian cell secretion expression system to ensure the close-to-native structures and post-translational modifications of the target proteins. We also implemented a strict quality control process, including purity testing, antibody-drug interaction verification, freezing and thawing tests, thermal stability tests, etc. 

Applications:

  • Immunogens for antibody drug development
  • Reagents used for CAR-T positive cell monitoring
  • Reagents for antibody screening and functional testing
  • Reagents for antibody affinity measurement
View All ECD Proteins

Hot Duggable Targets

Immune checkpoints are a class of proteins that regulate tumor immune microenvironment.

They can be classified into two categories, costimulatory immune checkpoints, such as OX40, GITR, ICOS, etc.; and co-suppressive immune checkpoints, such as PD1, CTLA-4, etc.

Right now there are a number of FDA approved drugs on co-suppressive targets, such as Yervoy, anti-CTLA-4 monoclonal antibody, Keytruda, anti-PD-1 monoclonal antibody and Tecentriq, anti-PD-L1 monoclonal antibody.

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DIMA Biotechnology LTD provide a full spectrum of functional proteins of new CAR T-cell targets.

All the proteins were made by using HEK293 mammalian cell secretion expression system and we implemented a strict quality control process, including purity testing, antibody-drug interaction verification, freezing and thawing Tests, thermal stability tests, etc.

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In recent years, the biopharmaceutical market is growing rapidly.

Compared with small molecule drugs, antibody drugs exhibit higher specificity and selectivity.

Therefore, it showed tremendous progresses in the treatment of hematological cancers and autoimmune diseases.

Due to complex tumor immune microenvironment, the development of therapeutic antibody drugs for solid tumor is more challenging.

ECD Proteins

sp-pme101745 tmem119 sp1

ECD Proteins

Human TMEM119 Protein, hFc Tag

SKU:  PME101745     Target:  TMEM119

Price:10μg $90.00 ; 50μg $320.00 ; 100μg $480.00

sp-pme101744 sectm1 sp1

ECD Proteins

Human SECTM1 Protein, hFc Tag

SKU:  PME101744     Target:  SECTM1

Price:10μg $95.00 ; 50μg $330.00 ; 100μg $500.00

sp-pme101743 comp sp1

ECD Proteins

Human COMP Protein, His Tag

SKU:  PME101743     Target:  COMP

Price:10μg $95.00 ; 50μg $330.00 ; 100μg $500.00

sp-pme101742 csf2rb sp1

ECD Proteins

Human CSF2RB Protein, His Tag

SKU:  PME101742     Target:  CSF2RB

Price:10μg $90.00 ; 50μg $320.00 ; 100μg $480.00

sp-pme101741 ggt1 sp1

ECD Proteins

Human GGT1 Protein, His Tag

SKU:  PME101741     Target:  GGT1

Price:10μg $95.00 ; 50μg $330.00 ; 100μg $500.00

sp-pme101740 tnfrsf11b sp1

ECD Proteins

Human TNFRSF11B Protein, His Tag

SKU:  PME101740     Target:  TNFRSF11B

Price:10μg $95.00 ; 50μg $330.00 ; 100μg $500.00

sp-pme101739 pecam1 sp1

ECD Proteins

Human PECAM1 Protein, His Tag

SKU:  PME101739     Target:  PECAM1

Price:10μg $100.00 ; 50μg $358.00 ; 100μg $528.00

sp-pme101738 crp sp1

ECD Proteins

Human CRP Protein, His Tag

SKU:  PME101738     Target:  CRP

Price:10μg $100.00 ; 50μg $358.00 ; 100μg $528.00

sp-pme101737 il18ra sp1

ECD Proteins

Human IL18RA Protein, His Tag

SKU:  PME101737     Target:  IL18RA

Price:10μg $95.00 ; 50μg $330.00 ; 100μg $500.00

sp-pme101757 lgr5 sp1 1

ECD Proteins

Human LGR5(447-561) Protein, hFc Tag

SKU:  PME101757     Target:  LGR5

Price:10μg $95.00 ; 50μg $330.00 ; 100μg $500.00

sp-pme101747 cb1 sp1 1

ECD Proteins

Human CB1(1-116) Protein, mFc Tag

SKU:  PME101747     Target:  CB1

Price:10μg $100.00 ; 50μg $358.00 ; 100μg $528.00

sp-pme101736 lilra4 sp1 1

ECD Proteins

Human LILRA4 Protein, His Tag

SKU:  PME101736     Target:  LILRA4

Price:10μg $100.00 ; 50μg $358.00 ; 100μg $528.00

sp-pme101735 lilra4 sp1 1

ECD Proteins

Human LILRA4 Protein, His Tag

SKU:  PME101735     Target:  LILRA4

Price:10μg $100.00 ; 50μg $358.00 ; 100μg $528.00

sp-pme101734 ighe sp1 1

ECD Proteins

Human IGHE(106-427) Protein, His Tag

SKU:  PME101734     Target:  IgHE

Price:10μg $100.00 ; 50μg $358.00 ; 100μg $528.00

sp-pme101733 il33 sp1 1

ECD Proteins

Human IL33(109-270) Protein, His Tag

SKU:  PME101733     Target:  IL33

Price:10μg $95.00 ; 50μg $330.00 ; 100μg $500.00

sp-pme101732 ighe sp1 1

ECD Proteins

Human IGHE(106-427) Protein, Flag and Twin-Strep Tag

SKU:  PME101732     Target:  IgHE

Price:10μg $100.00 ; 50μg $358.00 ; 100μg $528.00

sp-pme101730 sez6 sp1

ECD Proteins

Human SEZ6(833-925) Protein, hFc Tag

SKU:  PME101730     Target:  SEZ6

Price:10μg $79.00; 50μg $281.00 ; 100μg $422.00

sp-pme101729 sez6 sp1

ECD Proteins

Human SEZ6(768-835) Protein, hFc Tag

SKU:  PME101729     Target:  SEZ6

Price:10μg $79.00; 50μg $281.00 ; 100μg $422.00

sp-pme101728 sez6 sp1

ECD Proteins

Human SEZ6(705-768) Protein, hFc Tag

SKU:  PME101728     Target:  SEZ6

Price:10μg $100.00 ; 50μg $358.00 ; 100μg $528.00

sp-pme101727 sez6 sp1

ECD Proteins

Human SEZ6(528-592) Protein, hFc Tag

SKU:  PME101727     Target:  SEZ6

Price:10μg $79.00; 50μg $281.00 ; 100μg $422.00

sp-pme101726 sez6 sp1

ECD Proteins

Human SEZ6(415-529) Protein, hFc Tag

SKU:  PME101726     Target:  SEZ6

Price:10μg $79.00; 50μg $281.00 ; 100μg $422.00

sp-pme101725 sez6 sp1

ECD Proteins

Human SEZ6(355-415) Protein, hFc Tag

SKU:  PME101725     Target:  SEZ6

Price:10μg $79.00; 50μg $281.00 ; 100μg $422.00

sp-pme101724 tnfsf15 sp1

ECD Proteins

Human TNFSF15 MTQ Protein, His Tag

SKU:  PME101724     Target:  TNFSF15

Price:10μg $95.00 ; 50μg $330.00 ; 100μg $500.00

sp-pme101723 tnfsf15 sp1

ECD Proteins

Human TNFSF15 Protein, His Tag

SKU:  PME101723     Target:  TNFSF15

Price:10μg $95.00 ; 50μg $330.00 ; 100μg $500.00

sp-pme101722 ghrhr sp1

ECD Proteins

Human GHRHR Protein, hFc Tag

SKU:  PME101722     Target:  GHRHR

Price:10μg $95.00 ; 50μg $330.00 ; 100μg $500.00

sp-pme101721 drd2 sp1

ECD Proteins

Human DRD2 Protein, hFc Tag

SKU:  PME101721     Target:  DRD2

Price:10μg $90.00 ; 50μg $320.00 ; 100μg $480.00

sp-pme101720 neu1 sp1

ECD Proteins

Human NEU1 Protein, His Tag

SKU:  PME101720     Target:  NEU1

Price:10μg $100.00 ; 50μg $358.00 ; 100μg $528.00

sp-pme101719 lrp6 sp1

ECD Proteins

Human LRP6(20-1370) Protein, Flag Tag

SKU:  PME101719     Target:  LRP6

Price:10μg $91.00; 50μg $328.00 ; 100μg $488.00

sp-pme101718 nptx2 sp1

ECD Proteins

Human NPTX2 Protein, His Tag

SKU:  PME101718     Target:  NPTX2

Price:10μg $100.00 ; 50μg $358.00 ; 100μg $528.00

sp-pme101717 acvr2b sp1

ECD Proteins

Human ACVR2B(19-137) Protein, His Tag

SKU:  PME101717     Target:  ACVR2B

Price:10μg $95.00 ; 50μg $330.00 ; 100μg $500.00

sp-pme101716 acvr2a sp1

ECD Proteins

Human ACVR2A(20-135) Protein, His Tag

SKU:  PME101716     Target:  ACVR2A

Price:10μg $90.00 ; 50μg $320.00 ; 100μg $480.00

sp-pme101715 tgfb3 sp1

ECD Proteins

Human TGFB3(301-412) Protein, hFc Tag

SKU:  PME101715     Target:  TGFB3

Price:10μg $100.00 ; 50μg $358.00 ; 100μg $528.00