Extracellular Domain Protein (ECD)

DIMA BIOTECH offers over 1000 ECD proteins covering more than 600 single pass membrane protein targets. All the proteins were made using HEK293 mammalian cell secretion expression system to ensure the close-to-native structures and post-translational modifications of the target proteins. We also implemented a strict quality control process, including purity testing, antibody-drug interaction verification, freezing and thawing tests, thermal stability tests, etc.

Applications:

Immunogens for antibody drug development
Reagents used for CAR-T positive cell monitoring
Reagents for antibody screening and functional testing
Reagents for antibody affinity measurement

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Hot Duggable Targets

Immune checkpoint proteins

Immune checkpoints are a class of proteins that regulate tumor immune microenvironment.

They can be classified into two categories, costimulatory immune checkpoints, such as OX40, GITR, ICOS, etc.; and co-suppressive immune checkpoints, such as PD1, CTLA-4, etc.

Right now there are a number of FDA approved drugs on co-suppressive targets, such as Yervoy, anti-CTLA-4 monoclonal antibody, Keytruda, anti-PD-1 monoclonal antibody and Tecentriq, anti-PD-L1 monoclonal antibody.

Hematological cancer targets

DIMA Biotechnology LTD provide a full spectrum of functional proteins of new CAR T-cell targets.

All the proteins were made by using HEK293 mammalian cell secretion expression system and we implemented a strict quality control process, including purity testing, antibody-drug interaction verification, freezing and thawing Tests, thermal stability tests, etc.

Solid tumor targets

In recent years, the biopharmaceutical market is growing rapidly.

Compared with small molecule drugs, antibody drugs exhibit higher specificity and selectivity.

Therefore, it showed tremendous progresses in the treatment of hematological cancers and autoimmune diseases.

Due to complex tumor immune microenvironment, the development of therapeutic antibody drugs for solid tumor is more challenging.

ECD Proteins

ECD Proteins

Human DLL3(250-311) Protein, hFc Tag

SKU: PME101659 Target: DLL3

Price: 10μg $82.00 ; 50μg $320.00 ; 100μg $480.00

ECD Proteins

Human DLL3(216-273) Protein, hFc Tag

SKU: PME101658 Target: DLL3

Price: 10μg $82.00 ; 50μg $320.00 ; 100μg $480.00

ECD Proteins

Human FGFR2(313-363) Protein, hFc Tag

SKU: PME101657 Target: FGFR2

Price: 10μg $90.00 ; 50μg $320.00 ; 100μg $480.00

ECD Proteins

Human FGFR2(313-363) Protein, mFc Tag

SKU: PME101656 Target: FGFR2

Price: 10μg $90.00 ; 50μg $320.00 ; 100μg $480.00

ECD Proteins

Human GDF2 Protein, Flag Tag

SKU: PME101655 Target: GDF2

Price: 10μg $100.00 ; 50μg $358.00 ; 100μg $528.00

ECD Proteins

Human MET(25-562) Protein, His Tag

SKU: PME101654 Target: MET

Price: 10μg $100.00 ; 50μg $358.00 ; 100μg $528.00

ECD Proteins

Human CSF1R(105-202) Protein, hFc Tag

SKU: PME101652 Target: CSF1R

Price: 10μg $78.00 ; 50μg $310.00 ; 100μg $460.00

ECD Proteins

Human ACVR2B(67-87) Protein, mFc Tag

SKU: PME101651 Target: ACVR2B

Price: 10μg $95.00 ; 50μg $330.00 ; 100μg $500.00

ECD Proteins

Human ACVR2A(68-88) Protein, mFc Tag

SKU: PME101650 Target: ACVR2A

Price: 10μg $95.00 ; 50μg $330.00 ; 100μg $500.00

ECD Proteins

Human TGFB1(30-390) Protein, His Tag

SKU: PME101649 Target: TGFB1

Price: 10μg $82.00 ; 50μg $320.00 ; 100μg $480.00

ECD Proteins

Human DLL3(311-352) Protein, hFc Tag

SKU: PME101648 Target: DLL3

Price: 10μg $82.00 ; 50μg $320.00 ; 100μg $480.00

ECD Proteins

Human GPA33(135-235) Protein, hFc Tag

SKU: PME101647 Target: GPA33

Price: 10μg $95.00 ; 50μg $330.00 ; 100μg $500.00

ECD Proteins

Human GPA33(22-139) Protein, hFc Tag

SKU: PME101646 Target: GPA33

Price: 10μg $100.00 ; 50μg $358.00 ; 100μg $528.00

ECD Proteins

Human NRG1 Beta1(20-242) Protein, mFc Tag

SKU: PME101644 Target: NRG1 Beta1

Price: 10μg $95.00 ; 50μg $330.00 ; 100μg $500.00

ECD Proteins

Human NRG1 Beta1(20-242) Protein, hFc Tag

SKU: PME101643 Target: NRG1 Beta1

Price: 10μg $95.00 ; 50μg $330.00 ; 100μg $500.00

ECD Proteins

Human MET(740-932) Protein, hFc Tag

SKU: PME101642 Target: MET

Price: 10μg $100.00 ; 50μg $358.00 ; 100μg $528.00

ECD Proteins

Human MET(516-656) Protein, hFc Tag

SKU: PME101641 Target: MET

Price: 10μg $100.00 ; 50μg $358.00 ; 100μg $528.00

ECD Proteins

Human TRPV1 Protein, hFc Tag

SKU: PME101185 Target: TRPV1

Price: 10μg $90.00 ; 50μg $320.00 ; 100μg $480.00

ECD Proteins

Human PTPRG Protein, His Tag

SKU: PME101130 Target: PTPRG

Price: 10μg $100.00 ; 50μg $358.00 ; 100μg $528.00

ECD Proteins

Human PTPRG Protein, hFc Tag

SKU: PME101122 Target: PTPRG

Price: 10μg $100.00 ; 50μg $358.00 ; 100μg $528.00

ECD Proteins

Human USH2A Protein, N-hFc Tag

SKU: PME100702 Target: USH2A

Price: 10μg $95.00 ; 50μg $330.00 ; 100μg $500.00

ECD Proteins

Human USH2A Protein, hFc Tag

SKU: PME100701 Target: USH2A

Price: 10μg $90.00 ; 50μg $320.00 ; 100μg $480.00