Extracellular Domain Protein (ECD)

DIMA BIOTECH offers over 1000 ECD proteins covering more than 600 single pass membrane protein targets. All the proteins were made using HEK293 mammalian cell secretion expression system to ensure the close-to-native structures and post-translational modifications of the target proteins. We also implemented a strict quality control process, including purity testing, antibody-drug interaction verification, freezing and thawing tests, thermal stability tests, etc. 

Applications:

  • Immunogens for antibody drug development
  • Reagents used for CAR-T positive cell monitoring
  • Reagents for antibody screening and functional testing
  • Reagents for antibody affinity measurement
View All ECD Proteins

Hot Duggable Targets

Immune checkpoints are a class of proteins that regulate tumor immune microenvironment.

They can be classified into two categories, costimulatory immune checkpoints, such as OX40, GITR, ICOS, etc.; and co-suppressive immune checkpoints, such as PD1, CTLA-4, etc.

Right now there are a number of FDA approved drugs on co-suppressive targets, such as Yervoy, anti-CTLA-4 monoclonal antibody, Keytruda, anti-PD-1 monoclonal antibody and Tecentriq, anti-PD-L1 monoclonal antibody.

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DIMA Biotechnology LTD provide a full spectrum of functional proteins of new CAR T-cell targets.

All the proteins were made by using HEK293 mammalian cell secretion expression system and we implemented a strict quality control process, including purity testing, antibody-drug interaction verification, freezing and thawing Tests, thermal stability tests, etc.

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In recent years, the biopharmaceutical market is growing rapidly.

Compared with small molecule drugs, antibody drugs exhibit higher specificity and selectivity.

Therefore, it showed tremendous progresses in the treatment of hematological cancers and autoimmune diseases.

Due to complex tumor immune microenvironment, the development of therapeutic antibody drugs for solid tumor is more challenging.

ECD Proteins

sp-pme101682 5t4 sp1

ECD Proteins

Human 5T4(92-115) Protein, hFc Tag

SKU:  PME101682     Target:  5T4

Price:10μg $95.00 ; 50μg $330.00 ; 100μg $500.00

sp-pme101681 5t4 sp1

ECD Proteins

Human 5T4(32-91) Protein, hFc Tag

SKU:  PME101681     Target:  5T4

Price:10μg $68.00 ; 50μg $259.00 ; 100 μg $389.00

sp-pme101680 egfr sp1

ECD Proteins

Human EGFR(301-645) Protein, His Tag

SKU:  PME101680     Target:  EGFR

Price:10μg $82.00 ; 50μg $320.00 ; 100 μg $480.00

sp-pme101679 ctsl sp1

ECD Proteins

Human CTSL Protein, His Tag

SKU:  PME101679     Target:  CTSL

Price:10μg $90.00 ; 50μg $320.00 ; 100μg $480.00

sp-pme101678 ctsd sp1

ECD Proteins

Human CTSD Protein, His Tag

SKU:  PME101678     Target:  CTSD

Price:10μg $90.00 ; 50μg $320.00 ; 100μg $480.00

sp-pme101676 baff sp1

ECD Proteins

Human BAFF Protein, mFc-His Tag

SKU:  PME101676     Target:  BAFF

Price:10μg $96.00 ; 50μg $370.00 ; 100 μg $555.00

sp-pme101675 prlhr sp1

ECD Proteins

Human PRLHR Protein, hFc Tag

SKU:  PME101675     Target:  PRLHR

Price:10μg $90.00 ; 50μg $320.00 ; 100μg $480.00

sp-pme101674 cdh6 sp1

ECD Proteins

Human CDH6(487-615) Protein, hFc Tag

SKU:  PME101674     Target:  CDH6

Price:10μg $120.00 ; 50μg $450.00 ; 100 μg $660.00

sp-pme101673 cdh6 sp1

ECD Proteins

Human CDH6(384-486) Protein, hFc Tag

SKU:  PME101673     Target:  CDH6

Price:10μg $120.00 ; 50μg $450.00 ; 100 μg $660.00

sp-pme101672 cdh6 sp1

ECD Proteins

Human CDH6(269-383) Protein, hFc Tag

SKU:  PME101672     Target:  CDH6

Price:10μg $120.00 ; 50μg $450.00 ; 100 μg $660.00

sp-pme101671 cdh6 sp1

ECD Proteins

Human CDH6(160-268) Protein, hFc Tag

SKU:  PME101671     Target:  CDH6

Price:10μg $120.00 ; 50μg $450.00 ; 100 μg $660.00

sp-pme101670 cdh6 sp1

ECD Proteins

Human CDH6(54-159) Protein, hFc Tag

SKU:  PME101670     Target:  CDH6

Price:10μg $120.00 ; 50μg $450.00 ; 100 μg $660.00

sp-pme101669 hgf sp1

ECD Proteins

Human HGF Protein, Flag Tag

SKU:  PME101669     Target:  HGF

Price:10μg $82.00 ; 50μg $320.00 ; 100 μg $480.00

sp-pme101668 il20rb sp1

ECD Proteins

Human IL20RB Protein, hFc Tag

SKU:  PME101668     Target:  IL20RB

Price:10μg $100.00 ; 50μg $358.00 ; 100μg $528.00

sp-pme101667 egfr sp1

ECD Proteins

Human EGFR(25-389) Protein, His Tag

SKU:  PME101667     Target:  EGFR

Price:10μg $82.00 ; 50μg $320.00 ; 100 μg $480.00

sp-pme101666 cd4 sp1

ECD Proteins

Human CD4 Protein, His Tag

SKU:  PME101666     Target:  CD4

Price:10μg $72.00 ; 50μg $274.00 ; 100 μg $411.00

sp-pme m100124 light sp1

ECD Proteins

Mouse LIGHT Protein, hFc Tag

SKU:  PME-M100124     Target:  LIGHT

Price: 10μg $85.00 ; 50μg $330.00 ; 100μg $500.00

sp-pme m100123 dll3 sp1

ECD Proteins

Mouse DLL3(309-350) Protein, hFc Tag

SKU:  PME-M100123     Target:  DLL3

Price: 10μg $82.00 ; 50μg $320.00 ; 100μg $480.00

sp-pme m100122 gdf15 sp1

ECD Proteins

Mouse GDF15 Protein, hFc Tag

SKU:  PME-M100122     Target:  GDF15

Price: 10μg $82.00 ; 50μg $320.00 ; 100μg $480.00

sp-pme m100121 gdf15 sp1

ECD Proteins

Mouse GDF15 Protein, Flag Tag

SKU:  PME-M100121     Target:  GDF15

Price: 10μg $82.00 ; 50μg $320.00 ; 100μg $480.00

sp-pme m100120 cd46 sp1

ECD Proteins

Mouse CD46 Protein, hFc Tag

SKU:  PME-M100120     Target:  CD46

Price: 10μg $100.00 ; 50μg $358.00 ; 100μg $528.00

sp-pme c100084 sez6 sp1

ECD Proteins

Cynomolgus SEZ6 Protein, His Tag

SKU:  PME-C100084     Target:  SEZ6

Price: 10μg $79.00 ; 50μg $281.00 ; 100μg $422.00

sp-pme c100083 light sp1

ECD Proteins

Cynomolgus LIGHT Protein, hFc Tag

SKU:  PME-C100083     Target:  LIGHT

Price: 10μg $85.00 ; 50μg $330.00 ; 100μg $500.00

sp-pme c100082 fcgr3a sp1

ECD Proteins

Cynomolgus FCGR3A Protein, hFc Tag

SKU:  PME-C100082     Target:  FCGR3A

Price: 10μg $72.00 ; 50μg $274.00 ; 100μg $411.00

sp-pme c100081 tfrc sp1

ECD Proteins

Cynomolgus TFRC Protein, His Tag

SKU:  PME-C100081     Target:  TFRC

Price: 10μg $79.00 ; 50μg $281.00 ; 100μg $422.00

sp-pme c100080 met sp1

ECD Proteins

Cynomolgus MET Protein, His Tag

SKU:  PME-C100080     Target:  MET

Price: 10μg $79.00 ; 50μg $281.00 ; 100μg $422.00

sp-pme c100079 cd142 sp1

ECD Proteins

Cynomolgus CD142 Protein, His Tag

SKU:  PME-C100079     Target:  CD142

Price: 10μg $120.00 ; 50μg $450.00 ; 100μg $660.00

sp-pme101665 acvr1b sp1

ECD Proteins

Human ACVR1B Protein, hFc Tag

SKU:  PME101665     Target:  ACVR1B

Price: 10μg $100.00 ; 50μg $358.00 ; 100μg $528.00

sp-pme101664 epha3 sp1

ECD Proteins

Human EPHA3(436-541) Protein, hFc Tag

SKU:  PME101664     Target:  EPHA3

Price: 10μg $82.00 ; 50μg $320.00 ; 100μg $480.00

sp-pme101662 epha3 sp1

ECD Proteins

Human EPHA3(21-324) Protein, His Tag

SKU:  PME101662     Target:  EPHA3

Price: 10μg $82.00 ; 50μg $320.00 ; 100μg $480.00

sp-pme101661 dll3 sp1

ECD Proteins

Human DLL3(390-428) Protein, hFc Tag

SKU:  PME101661     Target:  DLL3

Price: 10μg $82.00 ; 50μg $320.00 ; 100μg $480.00

sp-pme101660 dll3 sp1

ECD Proteins

Human DLL3(352-390) Protein, hFc Tag

SKU:  PME101660     Target:  DLL3

Price: 10μg $82.00 ; 50μg $320.00 ; 100μg $480.00